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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Phosphatidylinositol binding clathrin assembly protein
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q14.2
Chromosome location (bp)
85957175 - 86069882
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly 1,2,3. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature 4. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 5,6,7. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors 8. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) 9,10....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Endocytosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13492 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0001540[amyloid-beta binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005545[1-phosphatidylinositol binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005769[early endosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005905[clathrin-coated pit] GO:0006897[endocytosis] GO:0006898[receptor-mediated endocytosis] GO:0006900[vesicle budding from membrane] GO:0007611[learning or memory] GO:0008021[synaptic vesicle] GO:0009986[cell surface] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016185[synaptic vesicle budding from presynaptic endocytic zone membrane] GO:0016188[synaptic vesicle maturation] GO:0016192[vesicle-mediated transport] GO:0016197[endosomal transport] GO:0030100[regulation of endocytosis] GO:0030132[clathrin coat of coated pit] GO:0030136[clathrin-coated vesicle] GO:0030276[clathrin binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031623[receptor internalization] GO:0031982[vesicle] GO:0032050[clathrin heavy chain binding] GO:0032880[regulation of protein localization] GO:0035459[vesicle cargo loading] GO:0042734[presynaptic membrane] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0045211[postsynaptic membrane] GO:0045296[cadherin binding] GO:0045334[clathrin-coated endocytic vesicle] GO:0045893[positive regulation of DNA-templated transcription] GO:0048156[tau protein binding] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048268[clathrin coat assembly] GO:0048471[perinuclear region of cytoplasm] GO:0050750[low-density lipoprotein particle receptor binding] GO:0055072[iron ion homeostasis] GO:0065003[protein-containing complex assembly] GO:0070381[endosome to plasma membrane transport vesicle] GO:0072583[clathrin-dependent endocytosis] GO:0097418[neurofibrillary tangle] GO:0097494[regulation of vesicle size] GO:0097753[membrane bending] GO:0098894[extrinsic component of presynaptic endocytic zone membrane] GO:0150093[amyloid-beta clearance by transcytosis] GO:1901216[positive regulation of neuron death] GO:1902004[positive regulation of amyloid-beta formation] GO:1902959[regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902961[positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902963[negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process] GO:1903077[negative regulation of protein localization to plasma membrane] GO:1905224[clathrin-coated pit assembly] GO:2000009[negative regulation of protein localization to cell surface] GO:2000369[regulation of clathrin-dependent endocytosis]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0001540[amyloid-beta binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005545[1-phosphatidylinositol binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005769[early endosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005905[clathrin-coated pit] GO:0006897[endocytosis] GO:0006898[receptor-mediated endocytosis] GO:0006900[vesicle budding from membrane] GO:0007409[axonogenesis] GO:0007611[learning or memory] GO:0008021[synaptic vesicle] GO:0009986[cell surface] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016185[synaptic vesicle budding from presynaptic endocytic zone membrane] GO:0016188[synaptic vesicle maturation] GO:0016192[vesicle-mediated transport] GO:0016197[endosomal transport] GO:0030097[hemopoiesis] GO:0030100[regulation of endocytosis] GO:0030132[clathrin coat of coated pit] GO:0030136[clathrin-coated vesicle] GO:0030276[clathrin binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031623[receptor internalization] GO:0031982[vesicle] GO:0032050[clathrin heavy chain binding] GO:0032880[regulation of protein localization] GO:0035459[vesicle cargo loading] GO:0042734[presynaptic membrane] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0045211[postsynaptic membrane] GO:0045296[cadherin binding] GO:0045334[clathrin-coated endocytic vesicle] GO:0045893[positive regulation of DNA-templated transcription] GO:0048156[tau protein binding] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048268[clathrin coat assembly] GO:0048471[perinuclear region of cytoplasm] GO:0048813[dendrite morphogenesis] GO:0050750[low-density lipoprotein particle receptor binding] GO:0055072[iron ion homeostasis] GO:0065003[protein-containing complex assembly] GO:0070381[endosome to plasma membrane transport vesicle] GO:0072583[clathrin-dependent endocytosis] GO:0097418[neurofibrillary tangle] GO:0097494[regulation of vesicle size] GO:0097753[membrane bending] GO:0098894[extrinsic component of presynaptic endocytic zone membrane] GO:0150093[amyloid-beta clearance by transcytosis] GO:1901216[positive regulation of neuron death] GO:1902004[positive regulation of amyloid-beta formation] GO:1902959[regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902961[positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902963[negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process] GO:1903077[negative regulation of protein localization to plasma membrane] GO:1905224[clathrin-coated pit assembly] GO:2000009[negative regulation of protein localization to cell surface] GO:2000369[regulation of clathrin-dependent endocytosis]
E9PI56 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Q13492 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149[SNARE binding] GO:0001540[amyloid-beta binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005545[1-phosphatidylinositol binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005769[early endosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005905[clathrin-coated pit] GO:0006897[endocytosis] GO:0006898[receptor-mediated endocytosis] GO:0006900[vesicle budding from membrane] GO:0007611[learning or memory] GO:0008021[synaptic vesicle] GO:0009986[cell surface] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016185[synaptic vesicle budding from presynaptic endocytic zone membrane] GO:0016188[synaptic vesicle maturation] GO:0016192[vesicle-mediated transport] GO:0016197[endosomal transport] GO:0030100[regulation of endocytosis] GO:0030132[clathrin coat of coated pit] GO:0030136[clathrin-coated vesicle] GO:0030276[clathrin binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031623[receptor internalization] GO:0031982[vesicle] GO:0032050[clathrin heavy chain binding] GO:0032880[regulation of protein localization] GO:0035459[vesicle cargo loading] GO:0042734[presynaptic membrane] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0045211[postsynaptic membrane] GO:0045296[cadherin binding] GO:0045334[clathrin-coated endocytic vesicle] GO:0045893[positive regulation of DNA-templated transcription] GO:0048156[tau protein binding] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048268[clathrin coat assembly] GO:0048471[perinuclear region of cytoplasm] GO:0050750[low-density lipoprotein particle receptor binding] GO:0055072[iron ion homeostasis] GO:0065003[protein-containing complex assembly] GO:0070381[endosome to plasma membrane transport vesicle] GO:0072583[clathrin-dependent endocytosis] GO:0097418[neurofibrillary tangle] GO:0097494[regulation of vesicle size] GO:0097753[membrane bending] GO:0098894[extrinsic component of presynaptic endocytic zone membrane] GO:0150093[amyloid-beta clearance by transcytosis] GO:1901216[positive regulation of neuron death] GO:1902004[positive regulation of amyloid-beta formation] GO:1902959[regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902961[positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902963[negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process] GO:1903077[negative regulation of protein localization to plasma membrane] GO:1905224[clathrin-coated pit assembly] GO:2000009[negative regulation of protein localization to cell surface] GO:2000369[regulation of clathrin-dependent endocytosis]
H0YD48 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
E9PKP6 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Q13492 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149[SNARE binding] GO:0001540[amyloid-beta binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005545[1-phosphatidylinositol binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005769[early endosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005905[clathrin-coated pit] GO:0006897[endocytosis] GO:0006898[receptor-mediated endocytosis] GO:0006900[vesicle budding from membrane] GO:0007611[learning or memory] GO:0008021[synaptic vesicle] GO:0009986[cell surface] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016185[synaptic vesicle budding from presynaptic endocytic zone membrane] GO:0016188[synaptic vesicle maturation] GO:0016192[vesicle-mediated transport] GO:0016197[endosomal transport] GO:0030100[regulation of endocytosis] GO:0030132[clathrin coat of coated pit] GO:0030136[clathrin-coated vesicle] GO:0030276[clathrin binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031623[receptor internalization] GO:0031982[vesicle] GO:0032050[clathrin heavy chain binding] GO:0032880[regulation of protein localization] GO:0035459[vesicle cargo loading] GO:0042734[presynaptic membrane] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0045211[postsynaptic membrane] GO:0045296[cadherin binding] GO:0045334[clathrin-coated endocytic vesicle] GO:0045893[positive regulation of DNA-templated transcription] GO:0048156[tau protein binding] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048268[clathrin coat assembly] GO:0048471[perinuclear region of cytoplasm] GO:0050750[low-density lipoprotein particle receptor binding] GO:0055072[iron ion homeostasis] GO:0065003[protein-containing complex assembly] GO:0070381[endosome to plasma membrane transport vesicle] GO:0072583[clathrin-dependent endocytosis] GO:0097418[neurofibrillary tangle] GO:0097494[regulation of vesicle size] GO:0097753[membrane bending] GO:0098894[extrinsic component of presynaptic endocytic zone membrane] GO:0150093[amyloid-beta clearance by transcytosis] GO:1901216[positive regulation of neuron death] GO:1902004[positive regulation of amyloid-beta formation] GO:1902959[regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902961[positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902963[negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process] GO:1903077[negative regulation of protein localization to plasma membrane] GO:1905224[clathrin-coated pit assembly] GO:2000009[negative regulation of protein localization to cell surface] GO:2000369[regulation of clathrin-dependent endocytosis]
H0YCY1 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
H0YEH1 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
H0YEF7 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
H0YEY8 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
E9PLJ8 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000149[SNARE binding] GO:0001540[amyloid-beta binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005545[1-phosphatidylinositol binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005769[early endosome] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005905[clathrin-coated pit] GO:0006897[endocytosis] GO:0006898[receptor-mediated endocytosis] GO:0006900[vesicle budding from membrane] GO:0007611[learning or memory] GO:0008021[synaptic vesicle] GO:0009986[cell surface] GO:0010629[negative regulation of gene expression] GO:0016020[membrane] GO:0016185[synaptic vesicle budding from presynaptic endocytic zone membrane] GO:0016188[synaptic vesicle maturation] GO:0016192[vesicle-mediated transport] GO:0016197[endosomal transport] GO:0030100[regulation of endocytosis] GO:0030132[clathrin coat of coated pit] GO:0030136[clathrin-coated vesicle] GO:0030276[clathrin binding] GO:0031267[small GTPase binding] GO:0031410[cytoplasmic vesicle] GO:0031623[receptor internalization] GO:0031982[vesicle] GO:0032050[clathrin heavy chain binding] GO:0032880[regulation of protein localization] GO:0035459[vesicle cargo loading] GO:0042734[presynaptic membrane] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0043547[positive regulation of GTPase activity] GO:0045211[postsynaptic membrane] GO:0045296[cadherin binding] GO:0045334[clathrin-coated endocytic vesicle] GO:0045893[positive regulation of DNA-templated transcription] GO:0048156[tau protein binding] GO:0048261[negative regulation of receptor-mediated endocytosis] GO:0048268[clathrin coat assembly] GO:0048471[perinuclear region of cytoplasm] GO:0050750[low-density lipoprotein particle receptor binding] GO:0055072[iron ion homeostasis] GO:0065003[protein-containing complex assembly] GO:0070381[endosome to plasma membrane transport vesicle] GO:0072583[clathrin-dependent endocytosis] GO:0097418[neurofibrillary tangle] GO:0097494[regulation of vesicle size] GO:0097753[membrane bending] GO:0098894[extrinsic component of presynaptic endocytic zone membrane] GO:0150093[amyloid-beta clearance by transcytosis] GO:1901216[positive regulation of neuron death] GO:1902004[positive regulation of amyloid-beta formation] GO:1902959[regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902961[positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process] GO:1902963[negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process] GO:1903077[negative regulation of protein localization to plasma membrane] GO:1905224[clathrin-coated pit assembly] GO:2000009[negative regulation of protein localization to cell surface] GO:2000369[regulation of clathrin-dependent endocytosis]
H0YE97 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
E9PK13 [Direct mapping] Phosphatidylinositol-binding clathrin assembly protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
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