GENERAL INFORMATIONi
Gene namei CLASP1
Synonyms KIAA0622, MAST1
Gene descriptioni Cytoplasmic linker associated protein 1
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 2
Cytoband
Chromosome location (bp) 121337776 - 121649476
Number of transcriptsi 10
Ensembl ENSG00000074054 (version 109)
Entrez gene 23332
HGNC HGNC:17088
UniProt Q7Z460 (UniProt - Evidence at protein level)
neXtProt NX_Q7Z460
GeneCards CLASP1
Antibodypedia CLASP1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. show less
Biological process (UniProt)i Cell cycle, Cell division, Mitosis
Gene summary (Entrez)i CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003).[supplied by OMIM, Mar 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
CLASP1-201
ENSP00000263710
ENST00000263710
Q7Z460
[Direct mapping] CLIP-associating protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005515 [protein binding]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007049 [cell cycle]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043232 [intracellular non-membrane-bounded organelle]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051128 [regulation of cellular component organization]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0072686 [mitotic spindle]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1538 aa
169.4 kDa 		No 0
CLASP1-202
ENSP00000386442
ENST00000409078
Q7Z460
[Direct mapping] CLIP-associating protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005515 [protein binding]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007049 [cell cycle]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043232 [intracellular non-membrane-bounded organelle]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051128 [regulation of cellular component organization]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0072686 [mitotic spindle]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1471 aa
162.1 kDa 		No 0
CLASP1-203
ENSP00000392886
ENST00000418989
C9J151
[Direct mapping] CLIP-associating protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 150 aa
16.5 kDa 		No 0
CLASP1-205
ENSP00000402101
ENST00000449975
C9JP76
[Direct mapping] CLIP-associating protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 110 aa
12 kDa 		No 0
CLASP1-206
ENSP00000400562
ENST00000452274
H0Y5T1
[Direct mapping] CLIP-associating protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043232 [intracellular non-membrane-bounded organelle]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
GO:0051128 [regulation of cellular component organization]
Show all
 1275 aa
139.9 kDa 		No 0
CLASP1-207
ENSP00000389372
ENST00000455322
F8WA11
[Direct mapping] CLIP-associating protein 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005815 [microtubule organizing center]
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043232 [intracellular non-membrane-bounded organelle]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
GO:0051128 [regulation of cellular component organization]
Show all
 1478 aa
162.8 kDa 		No 0
CLASP1-214
ENSP00000441625
ENST00000541377
Q7Z460
[Direct mapping] CLIP-associating protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000775 [chromosome, centromeric region]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0002162 [dystroglycan binding]
GO:0005515 [protein binding]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006903 [vesicle targeting]
GO:0007020 [microtubule nucleation]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007030 [Golgi organization]
GO:0007049 [cell cycle]
GO:0007052 [mitotic spindle organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0008017 [microtubule binding]
GO:0010458 [exit from mitosis]
GO:0010470 [regulation of gastrulation]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0016020 [membrane]
GO:0030953 [astral microtubule organization]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031023 [microtubule organizing center organization]
GO:0031111 [negative regulation of microtubule polymerization or depolymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031592 [centrosomal corona]
GO:0034453 [microtubule anchoring]
GO:0035371 [microtubule plus-end]
GO:0040001 [establishment of mitotic spindle localization]
GO:0043232 [intracellular non-membrane-bounded organelle]
GO:0043515 [kinetochore binding]
GO:0045180 [basal cortex]
GO:0045921 [positive regulation of exocytosis]
GO:0051010 [microtubule plus-end binding]
GO:0051128 [regulation of cellular component organization]
GO:0051294 [establishment of spindle orientation]
GO:0051301 [cell division]
GO:0051497 [negative regulation of stress fiber assembly]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0072686 [mitotic spindle]
GO:0090091 [positive regulation of extracellular matrix disassembly]
GO:0090162 [establishment of epithelial cell polarity]
GO:0090307 [mitotic spindle assembly]
GO:1903690 [negative regulation of wound healing, spreading of epidermal cells]
GO:1904261 [positive regulation of basement membrane assembly involved in embryonic body morphogenesis]
Show all
 1477 aa
163.1 kDa 		No 0
CLASP1-215
ENSP00000512981
ENST00000696935
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1559 aa
171.6 kDa 		No 0
CLASP1-216
ENSP00000515166
ENST00000700754
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1463 aa
161.3 kDa 		No 0
CLASP1-217
ENSP00000515167
ENST00000700755
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005828 [kinetochore microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0043515 [kinetochore binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1454 aa
160.4 kDa 		No 0

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