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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Bowman's capsule:
Not detected
Cells in glomeruli:
Not detected
Collecting ducts:
Not detected
Distal tubules:
High
Proximal tubules (cell body):
Not detected
Proximal tubules (microvilli):
Not detected
Protein profiling Multiplex tissuei
A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.
Cytoplasmic staining in distal tubules.
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
687.0
nTPM
HPA:
687.0
nTPM
GTEx:
264.1
nTPM
FANTOM5:
558.4
Scaled Tags Per Million
KIDNEY - Multiplex stainingi
Antibody localization in the annotated cell types/states/structures of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state/structure-specific markers, and, when applicable also subcellular localization. The scores are based on multiplex immunohistochemistry profiling in selected tissues.
Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity,
while additional locations are characterized by lower overlap and weaker antibody signal intensity.
The antibody of interest is reported in green, while cell types/states/structures are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.
- Antibody HPA014967
Main location
Distal tubules
No antibody overlap
No antibody overlap
Antibody overlap
>75%
Location
Cytoplasm
No antibody overlap
No antibody overlap
KIDNEY - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA014967
Antibody HPA018107
Bowman's capsule
Not detected
-
Cells in glomeruli
Not detected
Not detected
Cells in tubules
-
Medium
Collecting ducts
Not detected
-
Distal tubules
High
-
Proximal tubules (cell body)
Not detected
-
Proximal tubules (microvilli)
Not detected
-
KIDNEY - HPA RNA-seqi
The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.
Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.
Average nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
687.0
Female, age 58
Kidney sample 55 nTPM: 494.2
Cell types%
Cells in tubules:
60
Cells in glomeruli:
20
Fibroblasts:
5
Other cell types:
15
Female, age 67
Kidney sample 56 nTPM: 313.5
Cell types%
Cells in tubules:
70
Cells in glomeruli:
15
Fibroblasts:
10
Other cell types:
5
Female, age 55
Kidney sample 57 nTPM: 780.1
Cell types%
Cells in tubules:
80
Cells in glomeruli:
10
Fibroblasts:
5
Other cell types:
5
Male, age 46
Kidney sample 58 nTPM: 207
Cell types%
Cells in tubules:
60
Cells in glomeruli:
25
Fibroblasts:
5
Other cell types:
10
Female, age 57
Kidney sample 358 nTPM: 1174.5
Cell types%
Cells in tubules:
60
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
20
Male, age 78
Kidney sample 377 nTPM: 844.8
Cell types%
Cells in tubules:
65
Cells in glomeruli:
10
Fibroblasts:
5
Other cell types:
20
Male, age 73
Kidney sample 380 nTPM: 337.3
Cell types%
Cells in tubules:
60
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
20
Female, age 59
Kidney sample 394 nTPM: 903.5
Cell types%
Cells in tubules:
65
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
15
Female, age 48
Kidney sample 414 nTPM: 1128.5
Cell types%
Cells in tubules:
60
Cells in glomeruli:
5
Fibroblasts:
10
Other cell types:
25
KIDNEY - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
264.1
GTEx sample id
Sample description
nTPM
Kidney - Cortex Average nTPM: 70.4
Samples: 85
Max nTPM: 720.6
Min nTPM: 1.7
Std nTPM: 113.7
Median nTPM: 29.9
GTEX-ZYT6-2226-SM-5GIC9
30-39 years, male
720.6
GTEX-13OVL-1826-SM-5KLZR
50-59 years, male
548.0
GTEX-13112-2126-SM-5GCO4
50-59 years, male
477.4
GTEX-1OJC4-2326-SM-DTXA5
50-59 years, female
275.0
GTEX-ZDXO-0226-SM-4WKH7
60-69 years, male
271.1
GTEX-12696-0926-SM-5FQTV
60-69 years, male
192.0
GTEX-ZYFG-1626-SM-5GZYY
60-69 years, female
166.1
GTEX-S33H-1426-SM-EZ6L7
30-39 years, male
157.1
GTEX-ZE9C-1426-SM-4WKGM
60-69 years, male
155.2
GTEX-145MN-0326-SM-5QGQI
30-39 years, male
142.3
GTEX-147F4-2626-SM-5Q5CS
50-59 years, male
134.1
GTEX-11GS4-2326-SM-5A5KS
60-69 years, male
131.8
GTEX-Y5V6-2026-SM-5IFHO
60-69 years, male
118.1
GTEX-ZLFU-0926-SM-5P9F8
40-49 years, male
117.8
GTEX-1MUQO-2526-SM-E9TJN
60-69 years, male
116.4
GTEX-ZVZP-0926-SM-5GIDB
50-59 years, male
110.3
GTEX-11TTK-1926-SM-5PNW8
60-69 years, female
101.0
GTEX-17F97-1926-SM-7IGM4
50-59 years, male
86.7
GTEX-Y5V5-1226-SM-EYYVP
60-69 years, female
81.0
GTEX-T5JC-1526-SM-4DM68
20-29 years, male
78.5
GTEX-14E6D-2526-SM-5YYA9
50-59 years, male
75.2
GTEX-1LG7Y-2726-SM-D5OVW
50-59 years, male
72.1
GTEX-17F96-1926-SM-7MGWY
70-79 years, male
69.0
GTEX-13RTJ-2226-SM-5S2Q1
60-69 years, male
61.1
GTEX-1N2DW-1826-SM-EAZ54
50-59 years, male
61.1
GTEX-1BAJH-1826-SM-731DA
70-79 years, male
60.4
GTEX-1EKGG-2226-SM-7IGOA
60-69 years, male
53.8
GTEX-13OW6-1826-SM-5N9F9
50-59 years, male
53.6
GTEX-REY6-1826-SM-EAZAT
60-69 years, male
53.2
GTEX-1JJ6O-2526-SM-AHZ3J
60-69 years, male
52.4
GTEX-1KWVE-0826-SM-CXZKO
30-39 years, male
50.7
GTEX-1NV8Z-2226-SM-EXOJ2
60-69 years, male
50.1
GTEX-1HCU7-1826-SM-A9G2A
50-59 years, male
46.7
GTEX-15DYW-2026-SM-6AJBD
60-69 years, female
46.4
GTEX-1JMLX-1526-SM-AHZ3N
50-59 years, male
41.0
GTEX-11OF3-1326-SM-5N9FJ
60-69 years, male
37.8
GTEX-P4QS-1126-SM-3NMD5
60-69 years, male
36.3
GTEX-12WSG-0826-SM-5EQ5A
50-59 years, female
35.6
GTEX-17HHY-2326-SM-7KFSR
50-59 years, male
32.2
GTEX-1QP6S-1526-SM-EXUSG
40-49 years, male
31.4
GTEX-1GMR3-2426-SM-7MXV2
40-49 years, male
30.9
GTEX-XPVG-0526-SM-4B65N
50-59 years, male
30.5
GTEX-1HB9E-1826-SM-D4P33
50-59 years, male
29.9
GTEX-1497J-0826-SM-5NQAJ
60-69 years, male
29.4
GTEX-15CHQ-2126-SM-6871M
60-69 years, male
28.3
GTEX-1F48J-2226-SM-7MXTN
50-59 years, female
27.2
GTEX-14C39-2126-SM-664OH
40-49 years, male
26.4
GTEX-1GTWX-1826-SM-9QEHG
60-69 years, male
26.4
GTEX-RN64-1626-SM-48FD7
50-59 years, male
25.2
GTEX-1GF9V-1926-SM-9JGHE
60-69 years, male
25.2
GTEX-1HBPI-2026-SM-CE6RZ
50-59 years, male
24.7
GTEX-1IL2V-1826-SM-ARU7R
70-79 years, male
23.0
GTEX-1GN1U-2126-SM-AHZ4J
50-59 years, female
22.2
GTEX-ZC5H-1726-SM-5HL7X
40-49 years, female
21.9
GTEX-1I1GP-1926-SM-CNNQU
50-59 years, male
21.8
GTEX-1AX8Z-2326-SM-731CR
60-69 years, male
21.6
GTEX-T6MN-1826-SM-EXOHN
50-59 years, male
20.2
GTEX-1A3MW-2226-SM-73KUX
60-69 years, female
19.7
GTEX-1A8FM-2026-SM-7P8RN
50-59 years, female
19.3
GTEX-1H3NZ-2126-SM-9WPQ6
60-69 years, male
18.9
GTEX-13NYB-1726-SM-5N9G2
40-49 years, male
18.8
GTEX-QLQW-1626-SM-CMKFE
30-39 years, male
18.5
GTEX-QDVN-1626-SM-48TZC
50-59 years, male
16.8
GTEX-1IKK5-0926-SM-A9G2U
60-69 years, male
16.4
GTEX-1K9T9-1826-SM-CXZK2
50-59 years, female
15.9
GTEX-O5YV-1226-SM-EV795
60-69 years, female
15.9
GTEX-1JMQJ-1726-SM-E9U4V
50-59 years, male
15.6
GTEX-1H3VY-1926-SM-9JGHJ
50-59 years, male
14.7
GTEX-QDT8-1726-SM-EYYV6
30-39 years, female
14.5
GTEX-1C6VQ-2326-SM-7IGN1
50-59 years, male
13.6
GTEX-1JMPZ-1226-SM-ARU8Y
30-39 years, male
12.5
GTEX-1399S-0526-SM-5IJG8
30-39 years, female
11.9
GTEX-1E2YA-1626-SM-7MGXS
50-59 years, male
11.9
GTEX-1CB4J-1926-SM-7MGX8
60-69 years, male
11.7
GTEX-14C5O-2026-SM-5YYB1
60-69 years, male
11.1
GTEX-13OVI-1126-SM-5KLZF
60-69 years, female
10.8
GTEX-1J1OQ-1426-SM-AHZ3P
40-49 years, female
10.0
GTEX-16MT8-1926-SM-7EPGL
60-69 years, female
9.7
GTEX-1R9PO-1626-SM-E6CPT
60-69 years, female
9.2
GTEX-1N2EF-1426-SM-EXUSH
60-69 years, male
8.7
GTEX-1PWST-2226-SM-EVR3G
70-79 years, male
8.2
GTEX-1JMQK-1926-SM-CJI3B
60-69 years, male
6.9
GTEX-1GF9W-1326-SM-7P8PX
60-69 years, male
5.4
GTEX-13O1R-2526-SM-5N9FW
60-69 years, male
4.2
GTEX-NPJ8-2226-SM-3TW8D
40-49 years, male
1.7
Show allShow less
Kidney - Medulla Average nTPM: 264.1
Samples: 4
Max nTPM: 416.7
Min nTPM: 132.5
Std nTPM: 120.3
Median nTPM: 253.6
GTEX-TKQ2-0626-SM-EZ6LB
50-59 years, male
416.7
GTEX-R55E-2026-SM-EZ6L1
20-29 years, male
346.2
GTEX-T5JC-1626-SM-EZ6KW
20-29 years, male
161.0
GTEX-RU72-1926-SM-EAZ3F
50-59 years, female
132.5
KIDNEY - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Max subtype Scaled Tags Per Millioni
Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.
The Human Protein Atlas project is funded
