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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p11.23
Chromosome location (bp)
38400215 - 38468834
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000165[MAPK cascade] GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001764[neuron migration] GO:0001837[epithelial to mesenchymal transition] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005007[fibroblast growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0010518[positive regulation of phospholipase activity] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0017134[fibroblast growth factor binding] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0031410[cytoplasmic vesicle] GO:0033674[positive regulation of kinase activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043009[chordate embryonic development] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045595[regulation of cell differentiation] GO:0045597[positive regulation of cell differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0046777[protein autophosphorylation] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048705[skeletal system morphogenesis] GO:0051897[positive regulation of protein kinase B signaling] GO:0090722[receptor-receptor interaction] GO:1905564[positive regulation of vascular endothelial cell proliferation] GO:2000546[positive regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2001239[regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the breast and female genital organs Congenital malformations Congenital malformations of the musculoskeletal system Other congenital malformations Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
