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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p14
Chromosome location (bp)
39698109 - 39782792
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ubl conjugation pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P61086 [Direct mapping] Ubiquitin-conjugating enzyme E2 K
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Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0031625[ubiquitin protein ligase binding] GO:0032433[filopodium tip] GO:0032434[regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032446[protein modification by small protein conjugation] GO:0034450[ubiquitin-ubiquitin ligase activity] GO:0035458[cellular response to interferon-beta] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:1903265[positive regulation of tumor necrosis factor-mediated signaling pathway]
P61086 [Direct mapping] Ubiquitin-conjugating enzyme E2 K
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0031625[ubiquitin protein ligase binding] GO:0032446[protein modification by small protein conjugation] GO:0034450[ubiquitin-ubiquitin ligase activity] GO:0035458[cellular response to interferon-beta] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:1903265[positive regulation of tumor necrosis factor-mediated signaling pathway]
P61086 [Direct mapping] Ubiquitin-conjugating enzyme E2 K
Show all
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010994[free ubiquitin chain polymerization] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0031625[ubiquitin protein ligase binding] GO:0032446[protein modification by small protein conjugation] GO:0034450[ubiquitin-ubiquitin ligase activity] GO:0035458[cellular response to interferon-beta] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0060340[positive regulation of type I interferon-mediated signaling pathway] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070936[protein K48-linked ubiquitination] GO:1903265[positive regulation of tumor necrosis factor-mediated signaling pathway]
The Human Protein Atlas project is funded
