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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.32
Chromosome location (bp)
3652516 - 3736201
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008285[negative regulation of cell population proliferation] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Respiratory diseases Tracheobronchial diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
A1PQX5 [Target identity:100%; Query identity:100%] Tumor protein p73
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001822[kidney development] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008285[negative regulation of cell population proliferation] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009410[response to xenobiotic stimulus] GO:0010243[response to organonitrogen compound] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0043565[sequence-specific DNA binding] GO:0045665[negative regulation of neuron differentiation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Respiratory diseases Tracheobronchial diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039[p53 binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006298[mismatch repair] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007049[cell cycle] GO:0007346[regulation of mitotic cell cycle] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010468[regulation of gene expression] GO:0019901[protein kinase binding] GO:0030054[cell junction] GO:0042771[intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802[identical protein binding] GO:0043231[intracellular membrane-bounded organelle] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0051262[protein tetramerization] GO:0051726[regulation of cell cycle] GO:0060044[negative regulation of cardiac muscle cell proliferation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0097371[MDM2/MDM4 family protein binding] GO:0140297[DNA-binding transcription factor binding] GO:1901248[positive regulation of lung ciliated cell differentiation]
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