GENERAL INFORMATIONi
Gene namei HSP90AA1
Synonyms FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA
Gene descriptioni Heat shock protein 90 alpha family class A member 1
Protein classi Cancer-related genes
Enzymes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 14
Cytoband q32.31
Chromosome location (bp) 102080742 - 102139699
Number of transcriptsi 4
Ensembl ENSG00000080824 (version 109)
Entrez gene 3320
HGNC HGNC:5253
UniProt P07900 (UniProt - Evidence at protein level)
neXtProt NX_P07900
GeneCards HSP90AA1
Antibodypedia HSP90AA1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function 1, 2, 3, 4, 5, 6. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself 7. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle 8, 9. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 10. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels 11. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues 12. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment 13. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression 14. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes 15. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation 16. Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response 17, 18. show less
Molecular function (UniProt)i Chaperone, Hydrolase
Biological process (UniProt)i Host-virus interaction, Stress response
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
HSP90AA1-201
ENSP00000216281
ENST00000216281
P07900
[Direct mapping] Heat shock protein HSP 90-alpha
Show all
K9JA46
[Target identity:100%; Query identity:100%] Epididymis luminal secretory protein 52; Epididymis secretory sperm binding protein Li 65p; Heat shock protein 90kDa alpha (Cytosolic), class A member 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001764 [neuron migration]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002134 [UTP binding]
GO:0002135 [CTP binding]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003009 [skeletal muscle contraction]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006986 [response to unfolded protein]
GO:0007004 [telomere maintenance via telomerase]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0009410 [response to xenobiotic stimulus]
GO:0009651 [response to salt stress]
GO:0009986 [cell surface]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0017098 [sulfonylurea receptor binding]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0023026 [MHC class II protein complex binding]
GO:0030010 [establishment of cell polarity]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031526 [brush border membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032273 [positive regulation of protein polymerization]
GO:0032564 [dATP binding]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034605 [cellular response to heat]
GO:0034774 [secretory granule lumen]
GO:0036126 [sperm flagellum]
GO:0042026 [protein refolding]
GO:0042220 [response to cocaine]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043202 [lysosomal lumen]
GO:0043209 [myelin sheath]
GO:0043254 [regulation of protein-containing complex assembly]
GO:0043335 [protein unfolding]
GO:0043627 [response to estrogen]
GO:0044183 [protein folding chaperone]
GO:0044294 [dendritic growth cone]
GO:0044295 [axonal growth cone]
GO:0044325 [transmembrane transporter binding]
GO:0045040 [protein insertion into mitochondrial outer membrane]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045793 [positive regulation of cell size]
GO:0046677 [response to antibiotic]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048675 [axon extension]
GO:0050821 [protein stabilization]
GO:0051020 [GTPase binding]
GO:0051022 [Rho GDP-dissociation inhibitor binding]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051973 [positive regulation of telomerase activity]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0061684 [chaperone-mediated autophagy]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0071682 [endocytic vesicle lumen]
GO:0097110 [scaffold protein binding]
GO:0097226 [sperm mitochondrial sheath]
GO:0097524 [sperm plasma membrane]
GO:0097718 [disordered domain specific binding]
GO:0098586 [cellular response to virus]
GO:0099072 [regulation of postsynaptic membrane neurotransmitter receptor levels]
GO:0140662 [ATP-dependent protein folding chaperone]
GO:1902949 [positive regulation of tau-protein kinase activity]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905323 [telomerase holoenzyme complex assembly]
GO:1990782 [protein tyrosine kinase binding]
Show all
 732 aa
84.7 kDa 		No 0
HSP90AA1-202
ENSP00000335153
ENST00000334701
P07900
[Direct mapping] Heat shock protein HSP 90-alpha
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006457 [protein folding]
GO:0006839 [mitochondrial transport]
GO:0006986 [response to unfolded protein]
GO:0007004 [telomere maintenance via telomerase]
GO:0009408 [response to heat]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0023026 [MHC class II protein complex binding]
GO:0030010 [establishment of cell polarity]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030911 [TPR domain binding]
GO:0031396 [regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032273 [positive regulation of protein polymerization]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032880 [regulation of protein localization]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034605 [cellular response to heat]
GO:0034774 [secretory granule lumen]
GO:0042026 [protein refolding]
GO:0042470 [melanosome]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043025 [neuronal cell body]
GO:0043202 [lysosomal lumen]
GO:0043209 [myelin sheath]
GO:0043254 [regulation of protein-containing complex assembly]
GO:0043335 [protein unfolding]
GO:0044294 [dendritic growth cone]
GO:0044295 [axonal growth cone]
GO:0045040 [protein insertion into mitochondrial outer membrane]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046677 [response to antibiotic]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048675 [axon extension]
GO:0050821 [protein stabilization]
GO:0051020 [GTPase binding]
GO:0051082 [unfolded protein binding]
GO:0051131 [chaperone-mediated protein complex assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051973 [positive regulation of telomerase activity]
GO:0061684 [chaperone-mediated autophagy]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0071682 [endocytic vesicle lumen]
GO:0097110 [scaffold protein binding]
GO:0097718 [disordered domain specific binding]
GO:0098586 [cellular response to virus]
GO:0140662 [ATP-dependent protein folding chaperone]
GO:1902949 [positive regulation of tau-protein kinase activity]
GO:1904813 [ficolin-1-rich granule lumen]
GO:1905323 [telomerase holoenzyme complex assembly]
GO:1990782 [protein tyrosine kinase binding]
Show all
 854 aa
98.2 kDa 		No 0
HSP90AA1-203
ENSP00000450712
ENST00000553585
G3V2J8
[Direct mapping] Heat shock protein HSP 90-alpha
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0016887 [ATP hydrolysis activity]
GO:0051082 [unfolded protein binding]
GO:0140662 [ATP-dependent protein folding chaperone]
Show all
 174 aa
20.2 kDa 		No 0
HSP90AA1-209
ENSP00000489370
ENST00000558600
A0A0U1RR69
[Direct mapping] Heat shock protein HSP 90-alpha
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 100 aa
11 kDa 		No 0

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