GENERAL INFORMATIONi
Gene namei MEF2C
Synonyms
Gene descriptioni Myocyte enhancer factor 2C
Protein classi Disease related genes
Human disease related genes
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 5
Cytoband q14.3
Chromosome location (bp) 88717117 - 88904257
Number of transcriptsi 34
Ensembl ENSG00000081189 (version 109)
Entrez gene 4208
HGNC HGNC:6996
UniProt Q06413 (UniProt - Evidence at protein level)
neXtProt NX_Q06413
GeneCards MEF2C
Antibodypedia MEF2C antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. show less
Molecular function (UniProt)i Activator, Developmental protein, DNA-binding
Biological process (UniProt)i Apoptosis, Differentiation, Neurogenesis, Transcription, Transcription regulation
Gene summary (Entrez)i This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MEF2C-201
ENSP00000340874
ENST00000340208
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 483 aa
52.3 kDa 		No 0
MEF2C-202
ENSP00000389610
ENST00000424173
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 463 aa
50.2 kDa 		No 0
MEF2C-203
ENSP00000396219
ENST00000437473
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
A0A024RAL7
[Target identity:100%; Query identity:100%] MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 473 aa
51.2 kDa 		No 0
MEF2C-204
ENSP00000427286
ENST00000502831
D6RJA7
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 194 aa
21.8 kDa 		No 0
MEF2C-205
ENSP00000427163
ENST00000502983
D6RCM6
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 129 aa
14.9 kDa 		No 0
MEF2C-206
ENSP00000426465
ENST00000503075
D6RG14
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 87 aa
10.3 kDa 		No 0
MEF2C-207
ENSP00000487437
ENST00000503554
A0A0D9SGF3
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0005654 [nucleoplasm]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 327 aa
34.6 kDa 		No 0
MEF2C-209
ENSP00000421925
ENST00000504921
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
A0A024RAL7
[Target identity:100%; Query identity:100%] MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 473 aa
51.2 kDa 		No 0
MEF2C-210
ENSP00000425636
ENST00000506554
D6RJG6
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 399 aa
43.1 kDa 		No 0
MEF2C-211
ENSP00000423656
ENST00000506716
D6R942
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 227 aa
25 kDa 		No 0
MEF2C-212
ENSP00000424331
ENST00000507984
D6RB91
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 120 aa
14.1 kDa 		No 0
MEF2C-213
ENSP00000423597
ENST00000508569
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
A0A024RAL6
[Target identity:100%; Query identity:100%] MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 465 aa
50.3 kDa 		No 0
MEF2C-214
ENSP00000426442
ENST00000508610
D6RG21
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 126 aa
14.6 kDa 		No 0
MEF2C-216
ENSP00000427309
ENST00000509373
D6RJ95
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 28 aa
3.5 kDa 		No 0
MEF2C-217
ENSP00000422390
ENST00000510942
A0A0R4J2G5
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 433 aa
47 kDa 		No 0
MEF2C-220
ENSP00000423826
ENST00000513252
D6RC63
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 242 aa
26.6 kDa 		No 0
MEF2C-221
ENSP00000424606
ENST00000514015
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 441 aa
47.9 kDa 		No 0
MEF2C-222
ENSP00000426665
ENST00000514028
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 441 aa
47.9 kDa 		No 0
MEF2C-225
ENSP00000487538
ENST00000625585
A0A0D9SGI5
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 471 aa
51.1 kDa 		No 0
MEF2C-226
ENSP00000487430
ENST00000625674
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 463 aa
50.2 kDa 		No 0
MEF2C-227
ENSP00000487184
ENST00000626391
D8L7E9
[Direct mapping] Myocyte enhancer factor 2c; Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 393 aa
42.5 kDa 		No 0
MEF2C-228
ENSP00000487157
ENST00000627170
A0A0D9SG58
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
 151 aa
15.9 kDa 		No 0
MEF2C-229
ENSP00000486490
ENST00000627659
A0A0D9SFD0
[Direct mapping] MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_e; Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 431 aa
46.9 kDa 		No 0
MEF2C-230
ENSP00000486932
ENST00000627717
A0A0D9SFV9
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
 183 aa
18.9 kDa 		No 0
MEF2C-231
ENSP00000487311
ENST00000628656
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 417 aa
44.9 kDa 		No 0
MEF2C-232
ENSP00000486554
ENST00000629612
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
A0A024RAL6
[Target identity:100%; Query identity:100%] MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 465 aa
50.3 kDa 		No 0
MEF2C-234
ENSP00000485972
ENST00000631026
A0A0D9SET2
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 205 aa
22.9 kDa 		No 0
MEF2C-236
ENSP00000490525
ENST00000635898
A0A1B0GVI4
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 42 aa
5.1 kDa 		No 0
MEF2C-239
ENSP00000490473
ENST00000636294
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
A0A024RAL7
[Target identity:100%; Query identity:100%] MADS box transcription enhancer factor 2, polypeptide C (Myocyte enhancer factor 2C), isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 473 aa
51.2 kDa 		No 0
MEF2C-243
ENSP00000489865
ENST00000636541
A0A1B0GTW4
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 123 aa
14.3 kDa 		No 0
MEF2C-244
ENSP00000490630
ENST00000636998
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 441 aa
47.9 kDa 		No 0
MEF2C-249
ENSP00000490354
ENST00000637481
A0A1B0GV32
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007399 [nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046983 [protein dimerization activity]
GO:0048513 [animal organ development]
Show all
 462 aa
50.1 kDa 		No 0
MEF2C-254
ENSP00000490241
ENST00000637732
Q06413
[Direct mapping] Myocyte-specific enhancer factor 2C
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000165 [MAPK cascade]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001649 [osteoblast differentiation]
GO:0001764 [neuron migration]
GO:0001782 [B cell homeostasis]
GO:0001947 [heart looping]
GO:0001958 [endochondral ossification]
GO:0001974 [blood vessel remodeling]
GO:0002062 [chondrocyte differentiation]
GO:0002467 [germinal center formation]
GO:0002634 [regulation of germinal center formation]
GO:0002931 [response to ischemia]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003185 [sinoatrial valve morphogenesis]
GO:0003211 [cardiac ventricle formation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0007521 [muscle cell fate determination]
GO:0007611 [learning or memory]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010694 [positive regulation of alkaline phosphatase activity]
GO:0014033 [neural crest cell differentiation]
GO:0014902 [myotube differentiation]
GO:0016528 [sarcoplasm]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030220 [platelet formation]
GO:0030279 [negative regulation of ossification]
GO:0030318 [melanocyte differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0032991 [protein-containing complex]
GO:0035984 [cellular response to trichostatin A]
GO:0042100 [B cell proliferation]
GO:0042826 [histone deacetylase binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045652 [regulation of megakaryocyte differentiation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048167 [regulation of synaptic plasticity]
GO:0048513 [animal organ development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048666 [neuron development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050853 [B cell receptor signaling pathway]
GO:0051145 [smooth muscle cell differentiation]
GO:0051963 [regulation of synapse assembly]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060025 [regulation of synaptic activity]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060079 [excitatory postsynaptic potential]
GO:0060998 [regulation of dendritic spine development]
GO:0061333 [renal tubule morphogenesis]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072102 [glomerulus morphogenesis]
GO:0072160 [nephron tubule epithelial cell differentiation]
GO:0098794 [postsynapse]
GO:0140297 [DNA-binding transcription factor binding]
GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation]
GO:1904753 [negative regulation of vascular associated smooth muscle cell migration]
GO:1905563 [negative regulation of vascular endothelial cell proliferation]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000311 [regulation of AMPA receptor activity]
GO:2000727 [positive regulation of cardiac muscle cell differentiation]
GO:2000987 [positive regulation of behavioral fear response]
GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis]
GO:2001016 [positive regulation of skeletal muscle cell differentiation]
Show all
 441 aa
47.9 kDa 		No 0
MEF2C-257
ENSP00000516755
ENST00000707127
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Other congenital disorders
   Chromosomal abnormalities
   Other diseases
   Mental and behavioural disorders
Show all
 347 aa
36.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org