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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q21.12
Chromosome location (bp)
87503017 - 87713323
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Translocates drugs and phospholipids across the membrane 1,2,3,4. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins 5. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells 6,7,8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Translocase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A4D1D2 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c; Multidrug resistance protein 1
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Enzymes ENZYME proteins Metabolic proteins CD markers Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Disease related genes Human disease related genes Immune system diseases Other immune system diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006805[xenobiotic metabolic process] GO:0006869[lipid transport] GO:0008559[ABC-type xenobiotic transporter activity] GO:0009410[response to xenobiotic stimulus] GO:0009986[cell surface] GO:0015562[efflux transmembrane transporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0016887[ATP hydrolysis activity] GO:0022857[transmembrane transporter activity] GO:0031625[ubiquitin protein ligase binding] GO:0042626[ATPase-coupled transmembrane transporter activity] GO:0042910[xenobiotic transmembrane transporter activity] GO:0045332[phospholipid translocation] GO:0046865[terpenoid transport] GO:0046943[carboxylic acid transmembrane transporter activity] GO:0047484[regulation of response to osmotic stress] GO:0055085[transmembrane transport] GO:0070062[extracellular exosome] GO:0070633[transepithelial transport] GO:0072089[stem cell proliferation] GO:0090554[phosphatidylcholine floppase activity] GO:0090555[phosphatidylethanolamine flippase activity] GO:0098591[external side of apical plasma membrane] GO:0099038[ceramide floppase activity] GO:0099040[ceramide translocation] GO:0140115[export across plasma membrane] GO:0140326[ATPase-coupled intramembrane lipid transporter activity] GO:0140328[floppase activity] GO:0140359[ABC-type transporter activity] GO:0150104[transport across blood-brain barrier] GO:1901529[positive regulation of anion channel activity] GO:1905039[carboxylic acid transmembrane transport] GO:1990961[xenobiotic detoxification by transmembrane export across the plasma membrane] GO:1990962[xenobiotic transport across blood-brain barrier] GO:2001225[regulation of chloride transport]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes Human disease related genes Immune system diseases Other immune system diseases Musculoskeletal diseases Skeletal diseases Protein evidence (Ezkurdia et al 2014)
A4D1D2 [Target identity:100%; Query identity:100%] ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c; Multidrug resistance protein 1
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Enzymes ENZYME proteins Metabolic proteins CD markers Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Disease related genes Human disease related genes Immune system diseases Other immune system diseases Musculoskeletal diseases Skeletal diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000086[G2/M transition of mitotic cell cycle] GO:0000166[nucleotide binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006805[xenobiotic metabolic process] GO:0006869[lipid transport] GO:0008559[ABC-type xenobiotic transporter activity] GO:0009410[response to xenobiotic stimulus] GO:0009986[cell surface] GO:0015562[efflux transmembrane transporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0016887[ATP hydrolysis activity] GO:0022857[transmembrane transporter activity] GO:0031625[ubiquitin protein ligase binding] GO:0042626[ATPase-coupled transmembrane transporter activity] GO:0042910[xenobiotic transmembrane transporter activity] GO:0045332[phospholipid translocation] GO:0046865[terpenoid transport] GO:0046943[carboxylic acid transmembrane transporter activity] GO:0047484[regulation of response to osmotic stress] GO:0055085[transmembrane transport] GO:0070062[extracellular exosome] GO:0070633[transepithelial transport] GO:0072089[stem cell proliferation] GO:0090554[phosphatidylcholine floppase activity] GO:0090555[phosphatidylethanolamine flippase activity] GO:0098591[external side of apical plasma membrane] GO:0099038[ceramide floppase activity] GO:0099040[ceramide translocation] GO:0140115[export across plasma membrane] GO:0140326[ATPase-coupled intramembrane lipid transporter activity] GO:0140328[floppase activity] GO:0140359[ABC-type transporter activity] GO:0150104[transport across blood-brain barrier] GO:1901529[positive regulation of anion channel activity] GO:1905039[carboxylic acid transmembrane transport] GO:1990961[xenobiotic detoxification by transmembrane export across the plasma membrane] GO:1990962[xenobiotic transport across blood-brain barrier] GO:2001225[regulation of chloride transport]
The Human Protein Atlas project is funded
