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MRPL28
HPA
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  • MRPL28
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

MRPL28
Synonyms MAAT1, p15
Gene descriptioni

Full gene name according to HGNC.

Mitochondrial ribosomal protein L28
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Ribosomal proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 16
Cytoband p13.3
Chromosome location (bp) 366969 - 371289
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

6
Ensembl ENSG00000086504 (version 109)
Entrez gene 10573
HGNC HGNC:14484
UniProt Q13084 (UniProt - Evidence at protein level)
neXtProt NX_Q13084
GeneCards MRPL28
Antibodypedia MRPL28 antibodies


PROTEIN FUNCTION
Molecular function (UniProt)i

Keywords assigned by UniProt to proteins due to their particular molecular function.

Ribonucleoprotein, Ribosomal protein
Gene summary (Entrez)i

Useful information about the gene from Entrez

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
MRPL28-201
ENSP00000199706
ENST00000199706
Q13084
[Direct mapping] 39S ribosomal protein L28, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0032543 [mitochondrial translation]
GO:1990904 [ribonucleoprotein complex]
Show all
256 aa
30.2 kDa
No 0
MRPL28-202
ENSP00000374326
ENST00000389675
Q13084
[Direct mapping] 39S ribosomal protein L28, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0032543 [mitochondrial translation]
GO:1990904 [ribonucleoprotein complex]
Show all
256 aa
30.2 kDa
No 0
MRPL28-203
ENSP00000398684
ENST00000441883
A2IDC6
[Direct mapping] 39S ribosomal protein L28, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:1990904 [ribonucleoprotein complex]
Show all
240 aa
28.5 kDa
No 0
MRPL28-204
ENSP00000390399
ENST00000447696
Q4TT37
[Direct mapping] 39S ribosomal protein L28, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:1990904 [ribonucleoprotein complex]
Show all
218 aa
25.9 kDa
No 0
MRPL28-205
ENSP00000395305
ENST00000450882
A2IDC7
[Direct mapping] 39S ribosomal protein L28, mitochondrial
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:1990904 [ribonucleoprotein complex]
Show all
194 aa
23.1 kDa
No 0
MRPL28-210
ENSP00000497004
ENST00000648346
Q13084
[Direct mapping] 39S ribosomal protein L28, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0032543 [mitochondrial translation]
GO:1990904 [ribonucleoprotein complex]
Show all
256 aa
30.2 kDa
No 0

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