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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.33
Chromosome location (bp)
48872212 - 48876059
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress 1,2. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 3. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' 4. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux 5. Acts also a viral restriction factor by attenuating HIV-1 replication 6. Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation 7....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75807 [Direct mapping] Protein phosphatase 1 regulatory subunit 15A
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000164[protein phosphatase type 1 complex] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006417[regulation of translation] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0008157[protein phosphatase 1 binding] GO:0016020[membrane] GO:0019888[protein phosphatase regulator activity] GO:0019901[protein kinase binding] GO:0031400[negative regulation of protein modification process] GO:0032058[positive regulation of translational initiation in response to stress] GO:0032515[negative regulation of phosphoprotein phosphatase activity] GO:0032516[positive regulation of phosphoprotein phosphatase activity] GO:0034976[response to endoplasmic reticulum stress] GO:0035308[negative regulation of protein dephosphorylation] GO:0036496[regulation of translational initiation by eIF2 alpha dephosphorylation] GO:0045936[negative regulation of phosphate metabolic process] GO:0051726[regulation of cell cycle] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070972[protein localization to endoplasmic reticulum] GO:0072542[protein phosphatase activator activity] GO:1902310[positive regulation of peptidyl-serine dephosphorylation] GO:1903898[negative regulation of PERK-mediated unfolded protein response] GO:1903917[positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation]
The Human Protein Atlas project is funded
