GENERAL INFORMATIONi
Gene namei BAX
Synonyms BCL2L4
Gene descriptioni BCL2 associated X, apoptosis regulator
Protein classi Cancer-related genes
Human disease related genes
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 19
Cytoband q13.33
Chromosome location (bp) 48954815 - 48961798
Number of transcriptsi 6
Ensembl ENSG00000087088 (version 109)
Entrez gene 581
HGNC HGNC:959
UniProt Q07812 (UniProt - Evidence at protein level)
neXtProt NX_Q07812
GeneCards BAX
Antibodypedia BAX antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Plays a role in the mitochondrial apoptotic process 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) 12. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis 13, 14, 15, 16, 17, 18, 19, 20, 21, 22. Promotes activation of CASP3, and thereby apoptosis 23, 24, 25, 26, 27, 28, 29, 30, 31, 32. show less
Biological process (UniProt)i Apoptosis, Host-virus interaction
Gene summary (Entrez)i The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
BAX-201
ENSP00000293288
ENST00000293288
Q07812
[Direct mapping] Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001783 [B cell apoptotic process]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008053 [mitochondrial fusion]
GO:0008289 [lipid binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009636 [response to toxic substance]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0034620 [cellular response to unfolded protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097435 [supramolecular fiber organization]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 218 aa
24.2 kDa 		No 0
BAX-202
ENSP00000263262
ENST00000345358
Q07812
[Direct mapping] Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0001764 [neuron migration]
GO:0001776 [leukocyte homeostasis]
GO:0001777 [T cell homeostatic proliferation]
GO:0001782 [B cell homeostasis]
GO:0001783 [B cell apoptotic process]
GO:0001822 [kidney development]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0001974 [blood vessel remodeling]
GO:0002262 [myeloid cell homeostasis]
GO:0002352 [B cell negative selection]
GO:0002358 [B cell homeostatic proliferation]
GO:0002904 [positive regulation of B cell apoptotic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006808 [regulation of nitrogen utilization]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0007548 [sex differentiation]
GO:0008053 [mitochondrial fusion]
GO:0008283 [cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008584 [male gonad development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009566 [fertilization]
GO:0009611 [response to wounding]
GO:0009636 [response to toxic substance]
GO:0009651 [response to salt stress]
GO:0009791 [post-embryonic development]
GO:0010212 [response to ionizing radiation]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010332 [response to gamma radiation]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0021854 [hypothalamus development]
GO:0021987 [cerebral cortex development]
GO:0030544 [Hsp70 protein binding]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033599 [regulation of mammary gland epithelial cell proliferation]
GO:0034620 [cellular response to unfolded protein]
GO:0034644 [cellular response to UV]
GO:0035108 [limb morphogenesis]
GO:0035234 [ectopic germ cell programmed cell death]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0045136 [development of secondary sexual characteristics]
GO:0046666 [retinal cell programmed cell death]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0048087 [positive regulation of developmental pigmentation]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048515 [spermatid differentiation]
GO:0048597 [post-embryonic camera-type eye morphogenesis]
GO:0048678 [response to axon injury]
GO:0048872 [homeostasis of number of cells]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0050673 [epithelial cell proliferation]
GO:0051087 [chaperone binding]
GO:0051094 [positive regulation of developmental process]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051402 [neuron apoptotic process]
GO:0051434 [BH3 domain binding]
GO:0051649 [establishment of localization in cell]
GO:0051726 [regulation of cell cycle]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0060011 [Sertoli cell proliferation]
GO:0060041 [retina development in camera-type eye]
GO:0060057 [apoptotic process involved in mammary gland involution]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060068 [vagina development]
GO:0060402 [calcium ion transport into cytosol]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0070242 [thymocyte apoptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0071310 [cellular response to organic substance]
GO:0071944 [cell periphery]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097049 [motor neuron apoptotic process]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097435 [supramolecular fiber organization]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902262 [apoptotic process involved in blood vessel morphogenesis]
GO:1902263 [apoptotic process involved in embryonic digit morphogenesis]
GO:1902445 [regulation of mitochondrial membrane permeability involved in programmed necrotic cell death]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1904019 [epithelial cell apoptotic process]
GO:1904037 [positive regulation of epithelial cell apoptotic process]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2000243 [positive regulation of reproductive process]
GO:2000673 [positive regulation of motor neuron apoptotic process]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 192 aa
21.2 kDa 		No 0
BAX-203
ENSP00000346461
ENST00000354470
Q07812
[Direct mapping] Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001783 [B cell apoptotic process]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008053 [mitochondrial fusion]
GO:0008289 [lipid binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009636 [response to toxic substance]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0034620 [cellular response to unfolded protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097435 [supramolecular fiber organization]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 143 aa
15.8 kDa 		No 0
BAX-205
ENSP00000389971
ENST00000415969
Q07812
[Direct mapping] Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001783 [B cell apoptotic process]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008053 [mitochondrial fusion]
GO:0008289 [lipid binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009636 [response to toxic substance]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0034620 [cellular response to unfolded protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097435 [supramolecular fiber organization]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 179 aa
19.7 kDa 		No 0
BAX-208
ENSP00000426184
ENST00000506183
H0YA56
[Direct mapping] Apoptosis regulator BAX
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
Show all
 126 aa
14.1 kDa 		No 0
BAX-212
ENSP00000441413
ENST00000539787
I6LPK7
[Direct mapping] Apoptosis regulator BAX; BCL2-associated X protein theta
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
Show all
 140 aa
15.9 kDa 		No 0

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