GENERAL INFORMATIONi
Gene namei AURKA
Synonyms AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7
Gene descriptioni Aurora kinase A
Protein classi Cancer-related genes
Enzymes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 20
Cytoband q13.2
Chromosome location (bp) 56369389 - 56392337
Number of transcriptsi 13
Ensembl ENSG00000087586 (version 109)
Entrez gene 6790
HGNC HGNC:11393
UniProt O14965 (UniProt - Evidence at protein level)
neXtProt NX_O14965
GeneCards AURKA
Antibodypedia AURKA antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression 1, 2, 3, 4, 5, 6. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis 7, 8. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase 9. Required for initial activation of CDK1 at centrosomes 10, 11. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 12, 13, 14, 15, 16, 17, 18, 19. Regulates KIF2A tubulin depolymerase activity 20. Important for microtubule formation and/or stabilization 21. Required for normal axon formation 22. Plays a role in microtubule remodeling during neurite extension 23. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 24. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity 25. Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin 26, 27. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 28. show less
Molecular function (UniProt)i Kinase, Serine/threonine-protein kinase, Transferase
Biological process (UniProt)i Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
AURKA-201
ENSP00000321591
ENST00000312783
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0061523 [cilium disassembly]
GO:0072686 [mitotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1901796 [regulation of signal transduction by p53 class mediator]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-202
ENSP00000216911
ENST00000347343
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0061523 [cilium disassembly]
GO:0072686 [mitotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1901796 [regulation of signal transduction by p53 class mediator]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-203
ENSP00000360407
ENST00000371356
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0061523 [cilium disassembly]
GO:0072686 [mitotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1901796 [regulation of signal transduction by p53 class mediator]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-204
ENSP00000379243
ENST00000395907
A3KFJ0
[Direct mapping] Aurora kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
Show all
 347 aa
39.5 kDa 		No 0
AURKA-205
ENSP00000379247
ENST00000395911
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0061523 [cilium disassembly]
GO:0072686 [mitotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1901796 [regulation of signal transduction by p53 class mediator]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-206
ENSP00000379249
ENST00000395913
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0061523 [cilium disassembly]
GO:0072686 [mitotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1901796 [regulation of signal transduction by p53 class mediator]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-207
ENSP00000379250
ENST00000395914
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0061523 [cilium disassembly]
GO:0072686 [mitotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1901796 [regulation of signal transduction by p53 class mediator]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-208
ENSP00000379251
ENST00000395915
O14965
[Direct mapping] Aurora kinase A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000212 [meiotic spindle organization]
GO:0000226 [microtubule cytoskeleton organization]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005876 [spindle microtubule]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007052 [mitotic spindle organization]
GO:0007057 [spindle assembly involved in female meiosis I]
GO:0007098 [centrosome cycle]
GO:0007100 [mitotic centrosome separation]
GO:0009611 [response to wounding]
GO:0009948 [anterior/posterior axis specification]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010629 [negative regulation of gene expression]
GO:0014069 [postsynaptic density]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016570 [histone modification]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030030 [cell projection organization]
GO:0030496 [midbody]
GO:0031616 [spindle pole centrosome]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0032091 [negative regulation of protein binding]
GO:0032133 [chromosome passenger complex]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032465 [regulation of cytokinesis]
GO:0035174 [histone serine kinase activity]
GO:0036064 [ciliary basal body]
GO:0042585 [germinal vesicle]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043203 [axon hillock]
GO:0045120 [pronucleus]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046605 [regulation of centrosome cycle]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051642 [centrosome localization]
GO:0061523 [cilium disassembly]
GO:0071539 [protein localization to centrosome]
GO:0072686 [mitotic spindle]
GO:0072687 [meiotic spindle]
GO:0090141 [positive regulation of mitochondrial fission]
GO:0097421 [liver regeneration]
GO:0097431 [mitotic spindle pole]
GO:0098978 [glutamatergic synapse]
GO:0106310 [protein serine kinase activity]
GO:0140677 [molecular function activator activity]
GO:1900195 [positive regulation of oocyte maturation]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1990138 [neuron projection extension]
Show all
 403 aa
45.8 kDa 		No 0
AURKA-209
ENSP00000388073
ENST00000420474
A3KFJ1
[Direct mapping] Aurora kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
Show all
 188 aa
21 kDa 		No 0
AURKA-210
ENSP00000405042
ENST00000422322
Q5QPD2
[Direct mapping] Aurora kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0072686 [mitotic spindle]
Show all
 146 aa
16.1 kDa 		No 0
AURKA-211
ENSP00000393452
ENST00000441357
Q5QPD4
[Direct mapping] Aurora kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0051301 [cell division]
GO:0072686 [mitotic spindle]
Show all
 271 aa
30.7 kDa 		No 0
AURKA-212
ENSP00000401358
ENST00000451915
A3KFJ2
[Direct mapping] Aurora kinase A
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
 79 aa
8.6 kDa 		No 0
AURKA-213
ENSP00000405170
ENST00000456249
Q5QPD1
[Direct mapping] Aurora kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
Show all
 106 aa
11.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org