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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
3094362 - 3123999
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems 1. Acts as an activator of phospholipase C 2. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) 3. Together with GNAQ, required for heart development (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transducer
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P29992 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-11
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of ion transport and metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001501[skeletal system development] GO:0001508[action potential] GO:0001664[G protein-coupled receptor binding] GO:0001750[photoreceptor outer segment] GO:0003924[GTPase activity] GO:0003925[G protein activity] GO:0005246[calcium channel regulator activity] GO:0005515[protein binding] GO:0005525[GTP binding] GO:0005737[cytoplasm] GO:0005765[lysosomal membrane] GO:0005834[heterotrimeric G-protein complex] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007188[adenylate cyclase-modulating G protein-coupled receptor signaling pathway] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007207[phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007507[heart development] GO:0007603[phototransduction, visible light] GO:0008217[regulation of blood pressure] GO:0009649[entrainment of circadian clock] GO:0010259[multicellular organism aging] GO:0016004[phospholipase activator activity] GO:0016020[membrane] GO:0019001[guanyl nucleotide binding] GO:0031683[G-protein beta/gamma-subunit complex binding] GO:0032024[positive regulation of insulin secretion] GO:0045202[synapse] GO:0045634[regulation of melanocyte differentiation] GO:0046872[metal ion binding] GO:0048066[developmental pigmentation] GO:0060158[phospholipase C-activating dopamine receptor signaling pathway] GO:0070062[extracellular exosome] GO:0071467[cellular response to pH] GO:0086100[endothelin receptor signaling pathway] GO:0099103[channel activator activity] GO:0099105[ion channel modulating, G protein-coupled receptor signaling pathway] GO:0099107[ion channel regulator activity involved in G protein-coupled receptor signaling pathway] GO:1904888[cranial skeletal system development] GO:1990806[ligand-gated ion channel signaling pathway]
K7EL62 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-11
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Congenital disorders of metabolism Congenital disorders of ion transport and metabolism Protein evidence (Ezkurdia et al 2014)
A0A087WVZ3 [Direct mapping] Guanine nucleotide-binding protein subunit alpha-11
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DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Congenital disorders of metabolism Congenital disorders of ion transport and metabolism Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
