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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
ER degradation enhancing alpha-mannosidase like protein 2
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.22
Chromosome location (bp)
35115364 - 35147336
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner 1,2. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 3. Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9BV94 [Direct mapping] ER degradation-enhancing alpha-mannosidase-like protein 2
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MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004571[mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509[calcium ion binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005975[carbohydrate metabolic process] GO:0006986[response to unfolded protein] GO:0016020[membrane] GO:0019082[viral protein processing] GO:0036508[protein alpha-1,2-demannosylation] GO:0036509[trimming of terminal mannose on B branch] GO:0036510[trimming of terminal mannose on C branch] GO:0036511[trimming of first mannose on A branch] GO:0036512[trimming of second mannose on A branch] GO:0044322[endoplasmic reticulum quality control compartment] GO:0097466[ubiquitin-dependent glycoprotein ERAD pathway] GO:1904154[positive regulation of retrograde protein transport, ER to cytosol] GO:1904380[endoplasmic reticulum mannose trimming] GO:1904382[mannose trimming involved in glycoprotein ERAD pathway]
Q9BV94 [Direct mapping] ER degradation-enhancing alpha-mannosidase-like protein 2
Show all
MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004571[mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509[calcium ion binding] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005975[carbohydrate metabolic process] GO:0006986[response to unfolded protein] GO:0016020[membrane] GO:0019082[viral protein processing] GO:0036508[protein alpha-1,2-demannosylation] GO:0036509[trimming of terminal mannose on B branch] GO:0036510[trimming of terminal mannose on C branch] GO:0036511[trimming of first mannose on A branch] GO:0036512[trimming of second mannose on A branch] GO:0044322[endoplasmic reticulum quality control compartment] GO:0097466[ubiquitin-dependent glycoprotein ERAD pathway] GO:1904154[positive regulation of retrograde protein transport, ER to cytosol] GO:1904380[endoplasmic reticulum mannose trimming] GO:1904382[mannose trimming involved in glycoprotein ERAD pathway]
The Human Protein Atlas project is funded
