GENERAL INFORMATIONi
Gene namei NOS1
Synonyms nNOS, NOS
Gene descriptioni Nitric oxide synthase 1
Protein classi Cancer-related genes
Enzymes
FDA approved drug targets
Metabolic proteins
Plasma proteins
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 12
Cytoband q24.22
Chromosome location (bp) 117208142 - 117452170
Number of transcriptsi 3
Ensembl ENSG00000089250 (version 109)
Entrez gene 4842
HGNC HGNC:7872
UniProt P29475 (UniProt - Evidence at protein level)
neXtProt NX_P29475
GeneCards NOS1
Antibodypedia NOS1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. show less
Molecular function (UniProt)i Calmodulin-binding, Oxidoreductase
Ligand (UniProt)i FAD, Flavoprotein, FMN, Heme, Iron, Metal-binding, NADP
Gene summary (Entrez)i The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
NOS1-201
ENSP00000320758
ENST00000317775
P29475
[Direct mapping] Nitric oxide synthase, brain
Show all
B3VK56
[Target identity:100%; Query identity:100%] Nitric oxide synthase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0004517 [nitric-oxide synthase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0009408 [response to heat]
GO:0009725 [response to hormone]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0012506 [vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042178 [xenobiotic catabolic process]
GO:0042311 [vasodilation]
GO:0042383 [sarcolemma]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044249 [cellular biosynthetic process]
GO:0044325 [transmembrane transporter binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045454 [cell redox homeostasis]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046870 [cadmium ion binding]
GO:0046872 [metal ion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071944 [cell periphery]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:0098924 [retrograde trans-synaptic signaling by nitric oxide]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 1434 aa
161 kDa 		No 0
NOS1-202
ENSP00000337459
ENST00000338101
P29475
[Direct mapping] Nitric oxide synthase, brain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0004517 [nitric-oxide synthase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0009408 [response to heat]
GO:0009725 [response to hormone]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0012506 [vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042178 [xenobiotic catabolic process]
GO:0042311 [vasodilation]
GO:0042383 [sarcolemma]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044249 [cellular biosynthetic process]
GO:0044325 [transmembrane transporter binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045454 [cell redox homeostasis]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046870 [cadmium ion binding]
GO:0046872 [metal ion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071944 [cell periphery]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:0098924 [retrograde trans-synaptic signaling by nitric oxide]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 1468 aa
164.8 kDa 		No 0
NOS1-205
ENSP00000477999
ENST00000618760
P29475
[Direct mapping] Nitric oxide synthase, brain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Metabolic proteins
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001917 [photoreceptor inner segment]
GO:0002028 [regulation of sodium ion transport]
GO:0004517 [nitric-oxide synthase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006527 [arginine catabolic process]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0007520 [myoblast fusion]
GO:0009408 [response to heat]
GO:0009725 [response to hormone]
GO:0010181 [FMN binding]
GO:0010523 [negative regulation of calcium ion transport into cytosol]
GO:0012506 [vesicle membrane]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016529 [sarcoplasmic reticulum]
GO:0017080 [sodium channel regulator activity]
GO:0018119 [peptidyl-cysteine S-nitrosylation]
GO:0020037 [heme binding]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032991 [protein-containing complex]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033555 [multicellular organismal response to stress]
GO:0034617 [tetrahydrobiopterin binding]
GO:0034618 [arginine binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042178 [xenobiotic catabolic process]
GO:0042311 [vasodilation]
GO:0042383 [sarcolemma]
GO:0042995 [cell projection]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0044249 [cellular biosynthetic process]
GO:0044325 [transmembrane transporter binding]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045454 [cell redox homeostasis]
GO:0045776 [negative regulation of blood pressure]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046870 [cadmium ion binding]
GO:0046872 [metal ion binding]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051612 [negative regulation of serotonin uptake]
GO:0051926 [negative regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071944 [cell periphery]
GO:0097110 [scaffold protein binding]
GO:0098735 [positive regulation of the force of heart contraction]
GO:0098924 [retrograde trans-synaptic signaling by nitric oxide]
GO:1902307 [positive regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of calcium ion transmembrane transport via high voltage-gated calcium channel]
Show all
 1468 aa
164.8 kDa 		No 0

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