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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q25.3
Chromosome location (bp)
78214186 - 78225636
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis 1,2,3,4,5. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis 6. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules 7. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis 8. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules 9. May counteract a default induction of apoptosis in G2/M phase 10. The acetylated form represses STAT3 transactivation of target gene promoters 11. May play a role in neoplasia 12. Inhibitor of CASP3 and CASP7 13. Essential for the maintenance of mitochondrial integrity and function 14. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis 15,16. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform 17....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
H3BLT4 [Direct mapping] Baculoviral IAP repeat-containing protein 5
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0042981[regulation of apoptotic process] GO:0052548[regulation of endopeptidase activity]
A0A0B4J1S3 [Direct mapping] Baculoviral IAP repeat-containing protein 5
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0000226[microtubule cytoskeleton organization] GO:0000775[chromosome, centromeric region] GO:0005737[cytoplasm] GO:0007127[meiosis I] GO:0007346[regulation of mitotic cell cycle] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043524[negative regulation of neuron apoptotic process] GO:0052548[regulation of endopeptidase activity] GO:0061178[regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0061469[regulation of type B pancreatic cell proliferation]
O15392 [Direct mapping] Baculoviral IAP repeat-containing protein 5
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000278[mitotic cell cycle] GO:0000281[mitotic cytokinesis] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0001934[positive regulation of protein phosphorylation] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005876[spindle microtubule] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007059[chromosome segregation] GO:0007605[sensory perception of sound] GO:0008017[microtubule binding] GO:0008284[positive regulation of cell population proliferation] GO:0010466[negative regulation of peptidase activity] GO:0015630[microtubule cytoskeleton] GO:0019899[enzyme binding] GO:0030414[peptidase inhibitor activity] GO:0030496[midbody] GO:0031267[small GTPase binding] GO:0031503[protein-containing complex localization] GO:0032133[chromosome passenger complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0051087[chaperone binding] GO:0051256[mitotic spindle midzone assembly] GO:0051301[cell division] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1901970[positive regulation of mitotic sister chromatid separation] GO:1902425[positive regulation of attachment of mitotic spindle microtubules to kinetochore] GO:1903490[positive regulation of mitotic cytokinesis] GO:1990713[survivin complex]
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0042981[regulation of apoptotic process] GO:0052548[regulation of endopeptidase activity]
O15392 [Direct mapping] Baculoviral IAP repeat-containing protein 5
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000228[nuclear chromosome] GO:0000278[mitotic cell cycle] GO:0000281[mitotic cytokinesis] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0001934[positive regulation of protein phosphorylation] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005876[spindle microtubule] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007059[chromosome segregation] GO:0007605[sensory perception of sound] GO:0008017[microtubule binding] GO:0008284[positive regulation of cell population proliferation] GO:0010466[negative regulation of peptidase activity] GO:0015630[microtubule cytoskeleton] GO:0019899[enzyme binding] GO:0030414[peptidase inhibitor activity] GO:0030496[midbody] GO:0031267[small GTPase binding] GO:0031503[protein-containing complex localization] GO:0032133[chromosome passenger complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0051087[chaperone binding] GO:0051256[mitotic spindle midzone assembly] GO:0051301[cell division] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1901970[positive regulation of mitotic sister chromatid separation] GO:1902425[positive regulation of attachment of mitotic spindle microtubules to kinetochore] GO:1903490[positive regulation of mitotic cytokinesis] GO:1990713[survivin complex]
O15392 [Direct mapping] Baculoviral IAP repeat-containing protein 5
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228[nuclear chromosome] GO:0000278[mitotic cell cycle] GO:0000281[mitotic cytokinesis] GO:0000775[chromosome, centromeric region] GO:0000776[kinetochore] GO:0001934[positive regulation of protein phosphorylation] GO:0004869[cysteine-type endopeptidase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005874[microtubule] GO:0005876[spindle microtubule] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007049[cell cycle] GO:0007052[mitotic spindle organization] GO:0007059[chromosome segregation] GO:0007605[sensory perception of sound] GO:0008017[microtubule binding] GO:0008284[positive regulation of cell population proliferation] GO:0010466[negative regulation of peptidase activity] GO:0015630[microtubule cytoskeleton] GO:0019899[enzyme binding] GO:0030414[peptidase inhibitor activity] GO:0030496[midbody] GO:0031267[small GTPase binding] GO:0031503[protein-containing complex localization] GO:0032133[chromosome passenger complex] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043027[cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0051087[chaperone binding] GO:0051256[mitotic spindle midzone assembly] GO:0051301[cell division] GO:0051726[regulation of cell cycle] GO:0052548[regulation of endopeptidase activity] GO:0090267[positive regulation of mitotic cell cycle spindle assembly checkpoint] GO:1901970[positive regulation of mitotic sister chromatid separation] GO:1902425[positive regulation of attachment of mitotic spindle microtubules to kinetochore] GO:1903490[positive regulation of mitotic cytokinesis] GO:1990713[survivin complex]
The Human Protein Atlas project is funded
