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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q14.3
Chromosome location (bp)
66189195 - 66254622
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors 1,2. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells 3....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0001819[positive regulation of cytokine production] GO:0001960[negative regulation of cytokine-mediated signaling pathway] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0009615[response to virus] GO:0010468[regulation of gene expression] GO:0010556[regulation of macromolecule biosynthetic process] GO:0010933[positive regulation of macrophage tolerance induction] GO:0010936[negative regulation of macrophage cytokine production] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0031326[regulation of cellular biosynthetic process] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032494[response to peptidoglycan] GO:0032496[response to lipopolysaccharide] GO:0032695[negative regulation of interleukin-12 production] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0035556[intracellular signal transduction] GO:0042177[negative regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043242[negative regulation of protein-containing complex disassembly] GO:0043244[regulation of protein-containing complex disassembly] GO:0043330[response to exogenous dsRNA] GO:0043407[negative regulation of MAP kinase activity] GO:0044093[positive regulation of molecular function] GO:0045824[negative regulation of innate immune response] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070498[interleukin-1-mediated signaling pathway] GO:0070555[response to interleukin-1] GO:0071345[cellular response to cytokine stimulus]
Enzymes Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0000287[magnesium ion binding] GO:0001960[negative regulation of cytokine-mediated signaling pathway] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0009615[response to virus] GO:0010468[regulation of gene expression] GO:0010556[regulation of macromolecule biosynthetic process] GO:0010933[positive regulation of macrophage tolerance induction] GO:0010936[negative regulation of macrophage cytokine production] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0031326[regulation of cellular biosynthetic process] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032494[response to peptidoglycan] GO:0032496[response to lipopolysaccharide] GO:0032695[negative regulation of interleukin-12 production] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0035556[intracellular signal transduction] GO:0042177[negative regulation of protein catabolic process] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043242[negative regulation of protein-containing complex disassembly] GO:0043244[regulation of protein-containing complex disassembly] GO:0043330[response to exogenous dsRNA] GO:0043407[negative regulation of MAP kinase activity] GO:0044093[positive regulation of molecular function] GO:0045824[negative regulation of innate immune response] GO:0046982[protein heterodimerization activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0070498[interleukin-1-mediated signaling pathway] GO:0070555[response to interleukin-1] GO:0071345[cellular response to cytokine stimulus]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Protein evidence (Ezkurdia et al 2014)
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GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0034122[negative regulation of toll-like receptor signaling pathway] GO:0045824[negative regulation of innate immune response]
The Human Protein Atlas project is funded
