GENERAL INFORMATIONi
Gene namei NLRP1
Synonyms CARD7, CLR17.1, DEFCAP, DKFZp586O1822, KIAA0926, NAC, NALP1, SLEV1, VAMAS1
Gene descriptioni NLR family pyrin domain containing 1
Protein classi Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband p13.2
Chromosome location (bp) 5499415 - 5619424
Number of transcriptsi 26
Ensembl ENSG00000091592 (version 109)
Entrez gene 22861
HGNC HGNC:14374
UniProt Q9C000 (UniProt - Evidence at protein level)
neXtProt NX_Q9C000
GeneCards NLRP1
Antibodypedia NLRP1 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation 11, 12, 13. Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as cleavage by some human enteroviruses and rhinoviruses, double-stranded RNA, UV-B irradiation, or Val-boroPro inhibitor, and mediates the formation of the inflammasome polymeric complex composed of NLRP1, CASP1 and PYCARD/ASC 14, 15, 16, 17, 18, 19, 20, 21, 22, 23. In response to pathogen-associated signals, the N-terminal part of NLRP1 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (NACHT, LRR and PYD domains-containing protein 1, C-terminus), which polymerizes and associates with PYCARD/ASC to initiate the formation of the inflammasome complex: the NLRP1 inflammasome recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis 24, 25, 26, 27, 28. In the absence of GSDMD expression, the NLRP1 inflammasome is able to recruit and activate CASP8, leading to activation of gasdermin-E (GSDME) 29, 30. Activation of NLRP1 inflammasome is also required for HMGB1 secretion; the active cytokines and HMGB1 stimulate inflammatory responses 31. Binds ATP and shows ATPase activity 32, 33, 34. Plays an important role in antiviral immunity and inflammation in the human airway epithelium 35. Specifically recognizes a number of pathogen-associated signals: upon infection by human rhinoviruses 14 and 16 (HRV-14 and HRV-16), NLRP1 is cleaved and activated which triggers NLRP1-dependent inflammasome activation and IL18 secretion 36. Positive-strand RNA viruses, such as Semliki forest virus and long dsRNA activate the NLRP1 inflammasome, triggering IL1B release in a NLRP1-dependent fashion 37. Acts as a direct sensor for long dsRNA and thus RNA virus infection 38. May also be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner 39. The NLRP1 inflammasome is also activated in response to UV-B irradiation causing ribosome collisions: ribosome collisions cause phosphorylation and activation of NLRP1 in a MAP3K20-dependent manner, leading to pyroptosis 40. show less
Molecular function (UniProt)i Hydrolase, Protease
Biological process (UniProt)i Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Necrosis
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
NLRP1-201
ENSP00000262467
ENST00000262467
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1375 aa
154.9 kDa 		No 0
NLRP1-202
ENSP00000269280
ENST00000269280
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1429 aa
160.9 kDa 		No 0
NLRP1-203
ENSP00000346390
ENST00000354411
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1443 aa
162.2 kDa 		No 0
NLRP1-205
ENSP00000514459
ENST00000571307
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1198 aa
134.6 kDa 		No 0
NLRP1-206
ENSP00000459661
ENST00000571451
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1429 aa
160.9 kDa 		No 0
NLRP1-208
ENSP00000460475
ENST00000572272
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1473 aa
165.9 kDa 		No 0
NLRP1-211
ENSP00000458303
ENST00000576905
I3L0S2
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006954 [inflammatory response]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
Show all
 1429 aa
160.9 kDa 		No 0
NLRP1-212
ENSP00000460216
ENST00000577119
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1399 aa
157.3 kDa 		No 0
NLRP1-213
ENSP00000478516
ENST00000617618
Q9C000
[Direct mapping] NACHT, LRR and PYD domains-containing protein 1 NACHT, LRR and PYD domains-containing protein 1, C-terminus NACHT, LRR and PYD domains-containing protein 1, N-terminus
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002221 [pattern recognition receptor signaling pathway]
GO:0002376 [immune system process]
GO:0003690 [double-stranded DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0012501 [programmed cell death]
GO:0016787 [hydrolase activity]
GO:0016887 [ATP hydrolysis activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031347 [regulation of defense response]
GO:0032495 [response to muramyl dipeptide]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0043621 [protein self-association]
GO:0045087 [innate immune response]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0051260 [protein homooligomerization]
GO:0051402 [neuron apoptotic process]
GO:0051607 [defense response to virus]
GO:0061702 [inflammasome complex]
GO:0070269 [pyroptosis]
GO:0071493 [cellular response to UV-B]
GO:0072558 [NLRP1 inflammasome complex]
GO:0097264 [self proteolysis]
GO:0140374 [antiviral innate immune response]
GO:0140608 [cysteine-type endopeptidase activator activity]
GO:1904784 [NLRP1 inflammasome complex assembly]
Show all
 1473 aa
165.9 kDa 		No 0
NLRP1-216
ENSP00000514477
ENST00000699613
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1386 aa
156 kDa 		No 0
NLRP1-217
ENSP00000514478
ENST00000699614
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1327 aa
149.6 kDa 		No 0
NLRP1-226
ENSP00000514485
ENST00000699626
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 247 aa
26.8 kDa 		No 0
NLRP1-231
ENSP00000514491
ENST00000699633
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006954 [inflammatory response]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
Show all
 1477 aa
166.3 kDa 		No 0
NLRP1-232
ENSP00000514492
ENST00000699634
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1408 aa
157.5 kDa 		No 0
NLRP1-246
ENSP00000514532
ENST00000699707
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1341 aa
150.8 kDa 		No 0
NLRP1-249
ENSP00000514535
ENST00000699710
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1371 aa
154.5 kDa 		No 0
NLRP1-251
ENSP00000514537
ENST00000699712
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1162 aa
130.5 kDa 		No 0
NLRP1-256
ENSP00000514580
ENST00000699774
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 325 aa
36.2 kDa 		No 0
NLRP1-257
ENSP00000514581
ENST00000699775
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 967 aa
109 kDa 		No 0
NLRP1-260
ENSP00000514603
ENST00000699800
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 129 aa
14.3 kDa 		No 0
NLRP1-261
ENSP00000514604
ENST00000699801
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
15.8 kDa 		No 0
NLRP1-263
ENSP00000514606
ENST00000699803
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 98 aa
10.9 kDa 		No 0
NLRP1-266
ENSP00000514609
ENST00000699806
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 144 aa
15.7 kDa 		No 0
NLRP1-268
ENSP00000514611
ENST00000699808
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
 160 aa
17.4 kDa 		No 0
NLRP1-269
ENSP00000514612
ENST00000699809
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1061 aa
119.7 kDa 		No 0
NLRP1-270
ENSP00000514613
ENST00000699810
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Immune system diseases
   Other immune system diseases
   Skin diseases
   Skin and soft tissue diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1001 aa
113 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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