GENERAL INFORMATIONi
Gene namei TGFB2
Synonyms
Gene descriptioni Transforming growth factor beta 2
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Predicted locationi Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 1
Cytoband q41
Chromosome location (bp) 218345336 - 218444619
Number of transcriptsi 2
Ensembl ENSG00000092969 (version 109)
Entrez gene 7042
HGNC HGNC:11768
UniProt P61812 (UniProt - Evidence at protein level)
neXtProt NX_P61812
GeneCards TGFB2
Antibodypedia TGFB2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. show less
Molecular function (UniProt)i Growth factor, Mitogen
Gene summary (Entrez)i This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
TGFB2-201
ENSP00000355896
ENST00000366929
P61812
[Direct mapping] Transforming growth factor beta-2 proprotein Latency-associated peptide Transforming growth factor beta-2
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001501 [skeletal system development]
GO:0001540 [amyloid-beta binding]
GO:0001654 [eye development]
GO:0001666 [response to hypoxia]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0003179 [heart valve morphogenesis]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003274 [endocardial cushion fusion]
GO:0003289 [atrial septum primum morphogenesis]
GO:0003407 [neural retina development]
GO:0005102 [signaling receptor binding]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007435 [salivary gland morphogenesis]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008347 [glial cell migration]
GO:0008584 [male gonad development]
GO:0009410 [response to xenobiotic stimulus]
GO:0009611 [response to wounding]
GO:0009790 [embryo development]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009888 [tissue development]
GO:0010002 [cardioblast differentiation]
GO:0010629 [negative regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0010936 [negative regulation of macrophage cytokine production]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0016525 [negative regulation of angiogenesis]
GO:0030097 [hemopoiesis]
GO:0030199 [collagen fibril organization]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030424 [axon]
GO:0030509 [BMP signaling pathway]
GO:0030593 [neutrophil chemotaxis]
GO:0031069 [hair follicle morphogenesis]
GO:0031093 [platelet alpha granule lumen]
GO:0032147 [activation of protein kinase activity]
GO:0032570 [response to progesterone]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0034714 [type III transforming growth factor beta receptor binding]
GO:0035910 [ascending aorta morphogenesis]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell population proliferation]
GO:0042221 [response to chemical]
GO:0042416 [dopamine biosynthetic process]
GO:0042476 [odontogenesis]
GO:0042704 [uterine wall breakdown]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045216 [cell-cell junction organization]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045787 [positive regulation of cell cycle]
GO:0045823 [positive regulation of heart contraction]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048103 [somatic stem cell division]
GO:0048566 [embryonic digestive tract development]
GO:0048666 [neuron development]
GO:0048699 [generation of neurons]
GO:0048839 [inner ear development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050778 [positive regulation of immune response]
GO:0051781 [positive regulation of cell division]
GO:0051794 [regulation of timing of catagen]
GO:0051795 [positive regulation of timing of catagen]
GO:0051891 [positive regulation of cardioblast differentiation]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060065 [uterus development]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060412 [ventricular septum morphogenesis]
GO:0060413 [atrial septum morphogenesis]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1902256 [regulation of apoptotic process involved in outflow tract morphogenesis]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903701 [substantia propria of cornea development]
GO:1904888 [cranial skeletal system development]
GO:1905006 [negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:1905007 [positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
Show all
 442 aa
50.6 kDa 		Yes 0
TGFB2-202
ENSP00000355897
ENST00000366930
P61812
[Direct mapping] Transforming growth factor beta-2 proprotein Latency-associated peptide Transforming growth factor beta-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
   DeepTMHMM predicted secreted proteins
   DeepSig predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001501 [skeletal system development]
GO:0001540 [amyloid-beta binding]
GO:0001654 [eye development]
GO:0001666 [response to hypoxia]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0003179 [heart valve morphogenesis]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003274 [endocardial cushion fusion]
GO:0003289 [atrial septum primum morphogenesis]
GO:0003407 [neural retina development]
GO:0005102 [signaling receptor binding]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007435 [salivary gland morphogenesis]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008347 [glial cell migration]
GO:0008584 [male gonad development]
GO:0009410 [response to xenobiotic stimulus]
GO:0009611 [response to wounding]
GO:0009790 [embryo development]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009888 [tissue development]
GO:0010002 [cardioblast differentiation]
GO:0010629 [negative regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0010936 [negative regulation of macrophage cytokine production]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0016525 [negative regulation of angiogenesis]
GO:0030097 [hemopoiesis]
GO:0030199 [collagen fibril organization]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030424 [axon]
GO:0030509 [BMP signaling pathway]
GO:0030593 [neutrophil chemotaxis]
GO:0031069 [hair follicle morphogenesis]
GO:0031093 [platelet alpha granule lumen]
GO:0032147 [activation of protein kinase activity]
GO:0032570 [response to progesterone]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0034714 [type III transforming growth factor beta receptor binding]
GO:0035910 [ascending aorta morphogenesis]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell population proliferation]
GO:0042221 [response to chemical]
GO:0042416 [dopamine biosynthetic process]
GO:0042476 [odontogenesis]
GO:0042704 [uterine wall breakdown]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045216 [cell-cell junction organization]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045787 [positive regulation of cell cycle]
GO:0045823 [positive regulation of heart contraction]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048103 [somatic stem cell division]
GO:0048566 [embryonic digestive tract development]
GO:0048666 [neuron development]
GO:0048699 [generation of neurons]
GO:0048839 [inner ear development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050778 [positive regulation of immune response]
GO:0051781 [positive regulation of cell division]
GO:0051794 [regulation of timing of catagen]
GO:0051795 [positive regulation of timing of catagen]
GO:0051891 [positive regulation of cardioblast differentiation]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060065 [uterus development]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060412 [ventricular septum morphogenesis]
GO:0060413 [atrial septum morphogenesis]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1902256 [regulation of apoptotic process involved in outflow tract morphogenesis]
GO:1902895 [positive regulation of miRNA transcription]
GO:1903701 [substantia propria of cornea development]
GO:1904888 [cranial skeletal system development]
GO:1905006 [negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:1905007 [positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
Show all
 414 aa
47.7 kDa 		Yes 0

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