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CREM
HPA
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  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

  • SUBCELL

  • CANCER

  • BLOOD

  • CELL LINE

  • STRUCT & INT

  • CREM
PROTEIN SUMMARY GENE INFORMATION RNA DATA ANTIBODY DATA
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

CREM
Synonyms hCREM-2
Gene descriptioni

Full gene name according to HGNC.

CAMP responsive element modulator
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 10
Cytoband p11.21
Chromosome location (bp) 35126791 - 35212958
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

34
Ensembl ENSG00000095794 (version 109)
Entrez gene 1390
HGNC HGNC:2352
UniProt Q03060 (UniProt - Evidence at protein level)
neXtProt NX_Q03060
GeneCards CREM
Antibodypedia CREM antibodies


PROTEIN FUNCTION
Protein function (UniProt)i

Useful information about the protein provided by UniProt.

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation 1.... show less
Molecular function (UniProt)i

Keywords assigned by UniProt to proteins due to their particular molecular function.

Activator, Developmental protein, DNA-binding, Repressor
Biological process (UniProt)i

Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

Biological rhythms, Differentiation, Spermatogenesis, Transcription, Transcription regulation
Gene summary (Entrez)i

Useful information about the gene from Entrez

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]... show less
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
CREM-201
ENSP00000337138
ENST00000337656
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
299 aa
32.5 kDa
No 0
CREM-202
ENSP00000341875
ENST00000342105
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
245 aa
26.5 kDa
No 0
CREM-203
ENSP00000344365
ENST00000344351
E9PAR2
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
95 aa
10.9 kDa
No 0
CREM-204
ENSP00000265372
ENST00000345491
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
300 aa
32.5 kDa
No 0
CREM-205
ENSP00000345384
ENST00000348787
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
221 aa
24.4 kDa
No 0
CREM-206
ENSP00000346804
ENST00000354759
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
248 aa
27.5 kDa
No 0
CREM-207
ENSP00000349387
ENST00000356917
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
108 aa
12.1 kDa
No 0
CREM-208
ENSP00000354593
ENST00000361599
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
270 aa
29.7 kDa
No 0
CREM-210
ENSP00000363853
ENST00000374721
G5E998
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0050896 [response to stimulus]
Show all
269 aa
29.4 kDa
No 0
CREM-211
ENSP00000363858
ENST00000374726
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
137 aa
14.9 kDa
No 0
CREM-212
ENSP00000363866
ENST00000374734
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
236 aa
26.3 kDa
No 0
CREM-213
ENSP00000379225
ENST00000395887
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
282 aa
31 kDa
No 0
CREM-214
ENSP00000403938
ENST00000427847
A0A0A0MSU8
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
156 aa
16.8 kDa
No 0
CREM-215
ENSP00000393538
ENST00000429130
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
345 aa
37 kDa
No 0
CREM-216
ENSP00000420437
ENST00000460270
E9PAR2
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
95 aa
10.9 kDa
No 0
CREM-218
ENSP00000418336
ENST00000463314
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
138 aa
15.1 kDa
No 0
CREM-219
ENSP00000419684
ENST00000463960
C9K092
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0050896 [response to stimulus]
Show all
193 aa
21.5 kDa
No 0
CREM-222
ENSP00000419810
ENST00000468236
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
125 aa
14 kDa
No 0
CREM-224
ENSP00000473519
ENST00000469949
R4GN75
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
59 aa
6.3 kDa
No 0
CREM-226
ENSP00000420681
ENST00000473940
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
120 aa
13.4 kDa
No 0
CREM-227
ENSP00000419018
ENST00000474362
E9PB41
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
96 aa
11 kDa
No 0
CREM-228
ENSP00000417562
ENST00000474931
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
112 aa
12.7 kDa
No 0
CREM-229
ENSP00000420511
ENST00000479070
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
312 aa
33.8 kDa
No 0
CREM-232
ENSP00000417165
ENST00000484283
J3KR46
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0050896 [response to stimulus]
Show all
219 aa
24.7 kDa
No 0
CREM-233
ENSP00000418798
ENST00000487132
C9IYM9
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0050896 [response to stimulus]
Show all
221 aa
24.4 kDa
No 0
CREM-234
ENSP00000417807
ENST00000487763
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
121 aa
13.5 kDa
No 0
CREM-235
ENSP00000417460
ENST00000488328
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
109 aa
12.2 kDa
No 0
CREM-236
ENSP00000419075
ENST00000488741
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
102 aa
11.5 kDa
No 0
CREM-237
ENSP00000419924
ENST00000489321
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
137 aa
14.9 kDa
No 0
CREM-240
ENSP00000417327
ENST00000490511
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
113 aa
12.7 kDa
No 0
CREM-241
ENSP00000417399
ENST00000494479
C9J2J0
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
115 aa
11.6 kDa
No 0
CREM-242
ENSP00000417130
ENST00000495301
C9J5A7
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
Show all
78 aa
7.9 kDa
No 0
CREM-247
ENSP00000509489
ENST00000685392
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006687 [glycosphingolipid metabolic process]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
299 aa
32.5 kDa
No 0
CREM-248
ENSP00000510546
ENST00000686585
Q03060
[Direct mapping] cAMP-responsive element modulator
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0008140 [cAMP response element binding protein binding]
GO:0030154 [cell differentiation]
GO:0048511 [rhythmic process]
GO:0050896 [response to stimulus]
GO:1990589 [ATF4-CREB1 transcription factor complex]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
300 aa
32.5 kDa
No 0

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