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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q13.1
Chromosome location (bp)
38056311 - 38075701
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Actin-binding
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A024R1J5 [Target identity:100%; Query identity:100%] PRKCA-binding protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001664[G protein-coupled receptor binding] GO:0002092[positive regulation of receptor internalization] GO:0003779[actin binding] GO:0005080[protein kinase C binding] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006886[intracellular protein transport] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0007205[protein kinase C-activating G protein-coupled receptor signaling pathway] GO:0008021[synaptic vesicle] GO:0008022[protein C-terminus binding] GO:0014069[postsynaptic density] GO:0015844[monoamine transport] GO:0016020[membrane] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0021782[glial cell development] GO:0030666[endocytic vesicle membrane] GO:0032588[trans-Golgi network membrane] GO:0034315[regulation of Arp2/3 complex-mediated actin nucleation] GO:0034316[negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0036294[cellular response to decreased oxygen levels] GO:0042149[cellular response to glucose starvation] GO:0042734[presynaptic membrane] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043045[DNA methylation involved in embryo development] GO:0043046[DNA methylation involved in gamete generation] GO:0043113[receptor clustering] GO:0043231[intracellular membrane-bounded organelle] GO:0045161[neuronal ion channel clustering] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050796[regulation of insulin secretion] GO:0051015[actin filament binding] GO:0060292[long-term synaptic depression] GO:0071933[Arp2/3 complex binding] GO:0097061[dendritic spine organization] GO:0097062[dendritic spine maintenance] GO:0098842[postsynaptic early endosome] GO:0140090[membrane curvature sensor activity]
A0A024R1J5 [Target identity:100%; Query identity:100%] PRKCA-binding protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001664[G protein-coupled receptor binding] GO:0002092[positive regulation of receptor internalization] GO:0003779[actin binding] GO:0005080[protein kinase C binding] GO:0005102[signaling receptor binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0006886[intracellular protein transport] GO:0006890[retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum] GO:0007205[protein kinase C-activating G protein-coupled receptor signaling pathway] GO:0008021[synaptic vesicle] GO:0008022[protein C-terminus binding] GO:0014069[postsynaptic density] GO:0015844[monoamine transport] GO:0016020[membrane] GO:0019899[enzyme binding] GO:0019904[protein domain specific binding] GO:0021782[glial cell development] GO:0030666[endocytic vesicle membrane] GO:0032588[trans-Golgi network membrane] GO:0034315[regulation of Arp2/3 complex-mediated actin nucleation] GO:0034316[negative regulation of Arp2/3 complex-mediated actin nucleation] GO:0036294[cellular response to decreased oxygen levels] GO:0042149[cellular response to glucose starvation] GO:0042734[presynaptic membrane] GO:0042802[identical protein binding] GO:0043005[neuron projection] GO:0043045[DNA methylation involved in embryo development] GO:0043046[DNA methylation involved in gamete generation] GO:0043113[receptor clustering] GO:0043231[intracellular membrane-bounded organelle] GO:0045161[neuronal ion channel clustering] GO:0045202[synapse] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050796[regulation of insulin secretion] GO:0051015[actin filament binding] GO:0060292[long-term synaptic depression] GO:0071933[Arp2/3 complex binding] GO:0097061[dendritic spine organization] GO:0097062[dendritic spine maintenance] GO:0098842[postsynaptic early endosome] GO:0140090[membrane curvature sensor activity]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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