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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q13.1
Chromosome location (bp)
39223359 - 39244982
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin 1. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, Growth factor, Mitogen
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P01127 [Direct mapping] Platelet-derived growth factor subunit B
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A0A384NYY3 [Target identity:100%; Query identity:100%] Platelet-derived growth factor subunit B
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Candidate cardiovascular disease genes Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001892[embryonic placenta development] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002548[monocyte chemotaxis] GO:0003104[positive regulation of glomerular filtration] GO:0005161[platelet-derived growth factor receptor binding] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005788[endoplasmic reticulum lumen] GO:0005796[Golgi lumen] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007507[heart development] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0009611[response to wounding] GO:0009986[cell surface] GO:0010512[negative regulation of phosphatidylinositol biosynthetic process] GO:0010544[negative regulation of platelet activation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016020[membrane] GO:0016176[superoxide-generating NADPH oxidase activator activity] GO:0016323[basolateral plasma membrane] GO:0018105[peptidyl-serine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0031954[positive regulation of protein autophosphorylation] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032148[activation of protein kinase B activity] GO:0035655[interleukin-18-mediated signaling pathway] GO:0035793[positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0038001[paracrine signaling] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045840[positive regulation of mitotic nuclear division] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046982[protein heterodimerization activity] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048407[platelet-derived growth factor binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0050921[positive regulation of chemotaxis] GO:0051781[positive regulation of cell division] GO:0060326[cell chemotaxis] GO:0061098[positive regulation of protein tyrosine kinase activity] GO:0062023[collagen-containing extracellular matrix] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070528[protein kinase C signaling] GO:0070851[growth factor receptor binding] GO:0071363[cellular response to growth factor stimulus] GO:0071506[cellular response to mycophenolic acid] GO:0072126[positive regulation of glomerular mesangial cell proliferation] GO:0072255[metanephric glomerular mesangial cell development] GO:0072593[reactive oxygen species metabolic process] GO:0090280[positive regulation of calcium ion import] GO:1900127[positive regulation of hyaluronan biosynthetic process] GO:1902894[negative regulation of miRNA transcription] GO:1902895[positive regulation of miRNA transcription] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1905176[positive regulation of vascular associated smooth muscle cell dedifferentiation] GO:1990265[platelet-derived growth factor complex] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000573[positive regulation of DNA biosynthetic process] GO:2000591[positive regulation of metanephric mesenchymal cell migration]
P01127 [Direct mapping] Platelet-derived growth factor subunit B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Candidate cardiovascular disease genes Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001892[embryonic placenta development] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002548[monocyte chemotaxis] GO:0003104[positive regulation of glomerular filtration] GO:0005161[platelet-derived growth factor receptor binding] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005788[endoplasmic reticulum lumen] GO:0005796[Golgi lumen] GO:0006468[protein phosphorylation] GO:0007507[heart development] GO:0008083[growth factor activity] GO:0008284[positive regulation of cell population proliferation] GO:0009611[response to wounding] GO:0009986[cell surface] GO:0010512[negative regulation of phosphatidylinositol biosynthetic process] GO:0010544[negative regulation of platelet activation] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010811[positive regulation of cell-substrate adhesion] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014911[positive regulation of smooth muscle cell migration] GO:0016020[membrane] GO:0016176[superoxide-generating NADPH oxidase activator activity] GO:0016323[basolateral plasma membrane] GO:0018105[peptidyl-serine phosphorylation] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0030335[positive regulation of cell migration] GO:0031093[platelet alpha granule lumen] GO:0031954[positive regulation of protein autophosphorylation] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0032148[activation of protein kinase B activity] GO:0035655[interleukin-18-mediated signaling pathway] GO:0035793[positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0038001[paracrine signaling] GO:0042056[chemoattractant activity] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043406[positive regulation of MAP kinase activity] GO:0043410[positive regulation of MAPK cascade] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045737[positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045840[positive regulation of mitotic nuclear division] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046982[protein heterodimerization activity] GO:0048008[platelet-derived growth factor receptor signaling pathway] GO:0048018[receptor ligand activity] GO:0048146[positive regulation of fibroblast proliferation] GO:0048407[platelet-derived growth factor binding] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918[positive chemotaxis] GO:0050921[positive regulation of chemotaxis] GO:0051781[positive regulation of cell division] GO:0060326[cell chemotaxis] GO:0061098[positive regulation of protein tyrosine kinase activity] GO:0062023[collagen-containing extracellular matrix] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070528[protein kinase C signaling] GO:0070851[growth factor receptor binding] GO:0071363[cellular response to growth factor stimulus] GO:0071506[cellular response to mycophenolic acid] GO:0072126[positive regulation of glomerular mesangial cell proliferation] GO:0072255[metanephric glomerular mesangial cell development] GO:0072593[reactive oxygen species metabolic process] GO:0090280[positive regulation of calcium ion import] GO:1900127[positive regulation of hyaluronan biosynthetic process] GO:1902894[negative regulation of miRNA transcription] GO:1902895[positive regulation of miRNA transcription] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration] GO:1905064[negative regulation of vascular associated smooth muscle cell differentiation] GO:1905176[positive regulation of vascular associated smooth muscle cell dedifferentiation] GO:1990265[platelet-derived growth factor complex] GO:2000379[positive regulation of reactive oxygen species metabolic process] GO:2000573[positive regulation of DNA biosynthetic process] GO:2000591[positive regulation of metanephric mesenchymal cell migration]
A9UJN9 [Direct mapping] Platelet-derived growth factor subunit B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A9UJP0 [Direct mapping] Platelet-derived growth factor subunit B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of the lung and pleura Cancers of eye, brain, and central nervous system Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
