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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q11.2
Chromosome location (bp)
22920525 - 22929408
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA 1,2,3,4,5,6,7,8,9,10,11,12. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles 13,14,15. Methylates SUPT5H and may regulate its transcriptional elongation properties 16. May methylate the N-terminal region of MBD2 17. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation 18,19. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity 20. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 21. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation 22. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation 23. Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner 24. Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination 25. Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression 26. Symmetrically methylates NCL 27. Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity 28. Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
S-adenosyl-L-methionine
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O14744 [Direct mapping] Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
O14744 [Direct mapping] Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000387[spliceosomal snRNP assembly] GO:0000785[chromatin] GO:0002039[p53 binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0006325[chromatin organization] GO:0006353[DNA-templated transcription termination] GO:0006355[regulation of DNA-templated transcription] GO:0006479[protein methylation] GO:0007088[regulation of mitotic nuclear division] GO:0008168[methyltransferase activity] GO:0008276[protein methyltransferase activity] GO:0008327[methyl-CpG binding] GO:0008469[histone-arginine N-methyltransferase activity] GO:0016274[protein-arginine N-methyltransferase activity] GO:0016740[transferase activity] GO:0018216[peptidyl-arginine methylation] GO:0032259[methylation] GO:0032922[circadian regulation of gene expression] GO:0032991[protein-containing complex] GO:0034709[methylosome] GO:0034969[histone arginine methylation] GO:0035097[histone methyltransferase complex] GO:0035243[protein-arginine omega-N symmetric methyltransferase activity] GO:0035246[peptidyl-arginine N-methylation] GO:0042118[endothelial cell activation] GO:0042802[identical protein binding] GO:0043021[ribonucleoprotein complex binding] GO:0043985[histone H4-R3 methylation] GO:0044020[histone methyltransferase activity (H4-R3 specific)] GO:0044030[regulation of DNA methylation] GO:0044877[protein-containing complex binding] GO:0045596[negative regulation of cell differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0046982[protein heterodimerization activity] GO:0048026[positive regulation of mRNA splicing, via spliceosome] GO:0048511[rhythmic process] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070888[E-box binding] GO:0090161[Golgi ribbon formation] GO:0097421[liver regeneration] GO:1901796[regulation of signal transduction by p53 class mediator] GO:1904992[positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway]
O14744 [Direct mapping] Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
O14744 [Direct mapping] Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O14744 [Direct mapping] Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
G3V507 [Direct mapping] Protein arginine N-methyltransferase 5
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DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
