We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q13.2
Chromosome location (bp)
35401079 - 35404749
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals 1,2,3. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription 4,5,6,7....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006606[protein import into nucleus] GO:0006915[apoptotic process] GO:0007219[Notch signaling pathway] GO:0007249[I-kappaB kinase/NF-kappaB signaling] GO:0007253[cytoplasmic sequestering of NF-kappaB] GO:0008139[nuclear localization sequence binding] GO:0010468[regulation of gene expression] GO:0010745[negative regulation of macrophage derived foam cell differentiation] GO:0010875[positive regulation of cholesterol efflux] GO:0010888[negative regulation of lipid storage] GO:0019899[enzyme binding] GO:0031625[ubiquitin protein ligase binding] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032495[response to muramyl dipeptide] GO:0032496[response to lipopolysaccharide] GO:0033209[tumor necrosis factor-mediated signaling pathway] GO:0033256[I-kappaB/NF-kappaB complex] GO:0034142[toll-like receptor 4 signaling pathway] GO:0035994[response to muscle stretch] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0042994[cytoplasmic sequestering of transcription factor] GO:0043330[response to exogenous dsRNA] GO:0043392[negative regulation of DNA binding] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050729[positive regulation of inflammatory response] GO:0050853[B cell receptor signaling pathway] GO:0051059[NF-kappaB binding] GO:0051247[positive regulation of protein metabolic process] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0070417[cellular response to cold] GO:0070427[nucleotide-binding oligomerization domain containing 1 signaling pathway] GO:0070431[nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071356[cellular response to tumor necrosis factor] GO:1901222[regulation of NIK/NF-kappaB signaling]
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
