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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q12
Chromosome location (bp)
24365673 - 24379604
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems 1,2,3,4,5,6,7. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 8,9,10. Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (By similarity). Transactivates many genes involved in the cardiovascular system, including AGTR2, NPPB/BNP (in synergy with GATA4), NPPA/ANP/ANF and MYH7/beta-MHC (By similarity). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (By similarity). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during the developmental critical period, when auditory neurons depend on afferent input for survival (By similarity). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP) 11. Plays a role in adipocyte differentiation 12. May be involved in myoblast differentiation into myotubes 13. Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription 14. Binds to PPARG gene promoter and regulates its activity 15. Binds to PPARG and REG3G gene promoters (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Developmental protein, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001569[branching involved in blood vessel morphogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007507[heart development] GO:0007616[long-term memory] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0030178[negative regulation of Wnt signaling pathway] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0032091[negative regulation of protein binding] GO:0032760[positive regulation of tumor necrosis factor production] GO:0033173[calcineurin-NFAT signaling cascade] GO:0034644[cellular response to UV] GO:0035562[negative regulation of chromatin binding] GO:0035886[vascular associated smooth muscle cell differentiation] GO:0042975[peroxisome proliferator activated receptor binding] GO:0043524[negative regulation of neuron apoptotic process] GO:0043525[positive regulation of neuron apoptotic process] GO:0045333[cellular respiration] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048167[regulation of synaptic plasticity] GO:0048813[dendrite morphogenesis] GO:0050774[negative regulation of dendrite morphogenesis] GO:0051402[neuron apoptotic process] GO:0060074[synapse maturation] GO:0060291[long-term synaptic potentiation] GO:0071285[cellular response to lithium ion] GO:0097084[vascular associated smooth muscle cell development] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000297[negative regulation of synapse maturation] GO:2001235[positive regulation of apoptotic signaling pathway]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Immunoglobulin fold Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006954[inflammatory response] GO:0007616[long-term memory] GO:0016607[nuclear speck] GO:0030154[cell differentiation] GO:0031547[brain-derived neurotrophic factor receptor signaling pathway] GO:0033173[calcineurin-NFAT signaling cascade] GO:0043524[negative regulation of neuron apoptotic process] GO:0060291[long-term synaptic potentiation] GO:1902894[negative regulation of miRNA transcription] GO:1990837[sequence-specific double-stranded DNA binding]
The Human Protein Atlas project is funded
