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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Metabolic proteins Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.12
Chromosome location (bp)
45898621 - 45912155
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves 1,2,3,4,5,6. Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine 7. Plays an important role in HDL remodeling which involves modulating the size and composition of HDL 8. Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion 9. Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability 10....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P55058 [Direct mapping] Phospholipid transfer protein
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Metabolic proteins Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0006629[lipid metabolic process] GO:0006869[lipid transport] GO:0008035[high-density lipoprotein particle binding] GO:0008289[lipid binding] GO:0008429[phosphatidylethanolamine binding] GO:0008525[phosphatidylcholine transporter activity] GO:0008526[phosphatidylinositol transfer activity] GO:0010875[positive regulation of cholesterol efflux] GO:0015914[phospholipid transport] GO:0015918[sterol transport] GO:0019992[diacylglycerol binding] GO:0030169[low-density lipoprotein particle binding] GO:0031210[phosphatidylcholine binding] GO:0034189[very-low-density lipoprotein particle binding] GO:0034364[high-density lipoprotein particle] GO:0034375[high-density lipoprotein particle remodeling] GO:0035627[ceramide transport] GO:0046836[glycolipid transport] GO:0070300[phosphatidic acid binding] GO:0097001[ceramide binding] GO:0120009[intermembrane lipid transfer] GO:0120014[phospholipid transfer activity] GO:0120017[ceramide transfer activity] GO:0120019[phosphatidylcholine transfer activity] GO:0120020[cholesterol transfer activity] GO:0140337[diacylglyceride transfer activity] GO:0140338[sphingomyelin transfer activity] GO:0140339[phosphatidylglycerol transfer activity] GO:0140340[cerebroside transfer activity] GO:1901611[phosphatidylglycerol binding] GO:1904121[phosphatidylethanolamine transfer activity] GO:1990050[phosphatidic acid transfer activity]
The Human Protein Atlas project is funded
