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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.12
Chromosome location (bp)
46008908 - 46016561
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration 1,2,3. Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond 4. Cleaves NINJ1 to generate the Secreted ninjurin-1 form 5. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments 6. Degrades fibronectin but not laminin or Pz-peptide....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Metalloprotease, Protease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Collagen degradation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Cancers Cancers of male genital organs Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501[skeletal system development] GO:0001503[ossification] GO:0001934[positive regulation of protein phosphorylation] GO:0004175[endopeptidase activity] GO:0004222[metalloendopeptidase activity] GO:0004252[serine-type endopeptidase activity] GO:0005515[protein binding] GO:0005518[collagen binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006508[proteolysis] GO:0006915[apoptotic process] GO:0007566[embryo implantation] GO:0008233[peptidase activity] GO:0008237[metallopeptidase activity] GO:0008270[zinc ion binding] GO:0016477[cell migration] GO:0016787[hydrolase activity] GO:0022617[extracellular matrix disassembly] GO:0030198[extracellular matrix organization] GO:0030225[macrophage differentiation] GO:0030574[collagen catabolic process] GO:0031012[extracellular matrix] GO:0034614[cellular response to reactive oxygen species] GO:0035987[endodermal cell differentiation] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043388[positive regulation of DNA binding] GO:0045742[positive regulation of epidermal growth factor receptor signaling pathway] GO:0046872[metal ion binding] GO:0048013[ephrin receptor signaling pathway] GO:0050896[response to stimulus] GO:0050900[leukocyte migration] GO:0051549[positive regulation of keratinocyte migration] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071276[cellular response to cadmium ion] GO:0071492[cellular response to UV-A] GO:0090200[positive regulation of release of cytochrome c from mitochondria] GO:0150077[regulation of neuroinflammatory response] GO:1900122[positive regulation of receptor binding] GO:1904645[response to amyloid-beta] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904724[tertiary granule lumen] GO:1904813[ficolin-1-rich granule lumen] GO:2000697[negative regulation of epithelial cell differentiation involved in kidney development] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway] GO:2001258[negative regulation of cation channel activity] GO:2001268[negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
The Human Protein Atlas project is funded
