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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.12
Chromosome location (bp)
46118271 - 46129863
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor for TNFSF5/CD40LG 1. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P25942 [Direct mapping] Tumor necrosis factor receptor superfamily member 5
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CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934[positive regulation of protein phosphorylation] GO:0002376[immune system process] GO:0002768[immune response-regulating cell surface receptor signaling pathway] GO:0003823[antigen binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0006874[cellular calcium ion homeostasis] GO:0006954[inflammatory response] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0019899[enzyme binding] GO:0023035[CD40 signaling pathway] GO:0030168[platelet activation] GO:0030890[positive regulation of B cell proliferation] GO:0031625[ubiquitin protein ligase binding] GO:0032735[positive regulation of interleukin-12 production] GO:0034341[response to type II interferon] GO:0035631[CD40 receptor complex] GO:0035666[TRIF-dependent toll-like receptor signaling pathway] GO:0038023[signaling receptor activity] GO:0042100[B cell proliferation] GO:0042113[B cell activation] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042832[defense response to protozoan] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406[positive regulation of MAP kinase activity] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043547[positive regulation of GTPase activity] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048304[positive regulation of isotype switching to IgG isotypes] GO:0050776[regulation of immune response] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051607[defense response to virus] GO:0065003[protein-containing complex assembly] GO:0070062[extracellular exosome] GO:0071260[cellular response to mechanical stimulus] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0090037[positive regulation of protein kinase C signaling] GO:2000353[positive regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
