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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.13
Chromosome location (bp)
50888916 - 50931437
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005694[chromosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010468[regulation of gene expression] GO:0046872[metal ion binding] GO:0090575[RNA polymerase II transcription regulator complex]
Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005694[chromosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010468[regulation of gene expression] GO:0046872[metal ion binding] GO:0090575[RNA polymerase II transcription regulator complex]
Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005694[chromosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010468[regulation of gene expression] GO:0046872[metal ion binding] GO:0090575[RNA polymerase II transcription regulator complex]
Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005694[chromosome] GO:0006357[regulation of transcription by RNA polymerase II] GO:0010468[regulation of gene expression] GO:0046872[metal ion binding] GO:0090575[RNA polymerase II transcription regulator complex]
Q9H2P0 [Direct mapping] Activity-dependent neuroprotector homeobox protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Cancer-related genes Mutated cancer genes Disease related genes Human disease related genes Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001933[negative regulation of protein phosphorylation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0005507[copper ion binding] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005694[chromosome] GO:0005737[cytoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007614[short-term memory] GO:0008013[beta-catenin binding] GO:0009743[response to carbohydrate] GO:0010035[response to inorganic substance] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010835[regulation of protein ADP-ribosylation] GO:0010976[positive regulation of neuron projection development] GO:0019934[cGMP-mediated signaling] GO:0030182[neuron differentiation] GO:0030424[axon] GO:0030425[dendrite] GO:0031668[cellular response to extracellular stimulus] GO:0032091[negative regulation of protein binding] GO:0032147[activation of protein kinase activity] GO:0033484[nitric oxide homeostasis] GO:0042277[peptide binding] GO:0043025[neuronal cell body] GO:0043524[negative regulation of neuron apoptotic process] GO:0044849[estrous cycle] GO:0045773[positive regulation of axon extension] GO:0046872[metal ion binding] GO:0048487[beta-tubulin binding] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050805[negative regulation of synaptic transmission] GO:0051402[neuron apoptotic process] GO:0051965[positive regulation of synapse assembly] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0090575[RNA polymerase II transcription regulator complex]
A0A2R8YCL6 [Direct mapping] Activity-dependent neuroprotector homeobox protein
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SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
A0A2R8Y6X0 [Direct mapping] Activity-dependent neuroprotector homeobox protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Human disease related genes Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
