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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.31
Chromosome location (bp)
57168753 - 57266641
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis 1. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A 2,3. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes 4. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor 5. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors 6. Promotes the expression of HAMP, this is repressed by its interaction with ERFE 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Cytokine, Developmental protein, Growth factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Chondrogenesis, Differentiation, Osteogenesis
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P18075 [Direct mapping] Bone morphogenetic protein 7
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A8K571 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 7 (Osteogenic protein 1), isoform CRA_b; cDNA FLJ78019, highly similar to Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1), mRNA; cDNA, FLJ92758, Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1)(BMP7), mRNA
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THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001501[skeletal system development] GO:0001503[ossification] GO:0001654[eye development] GO:0001656[metanephros development] GO:0001657[ureteric bud development] GO:0001707[mesoderm formation] GO:0001822[kidney development] GO:0001823[mesonephros development] GO:0001837[epithelial to mesenchymal transition] GO:0003272[endocardial cushion formation] GO:0003344[pericardium morphogenesis] GO:0005125[cytokine activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0007389[pattern specification process] GO:0007411[axon guidance] GO:0007435[salivary gland morphogenesis] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008283[cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0009880[embryonic pattern specification] GO:0009887[animal organ morphogenesis] GO:0010628[positive regulation of gene expression] GO:0010664[negative regulation of striated muscle cell apoptotic process] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0010862[positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942[positive regulation of cell death] GO:0016358[dendrite development] GO:0021502[neural fold elevation formation] GO:0030154[cell differentiation] GO:0030326[embryonic limb morphogenesis] GO:0030501[positive regulation of bone mineralization] GO:0030509[BMP signaling pathway] GO:0030855[epithelial cell differentiation] GO:0030858[positive regulation of epithelial cell differentiation] GO:0030902[hindbrain development] GO:0031982[vesicle] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032355[response to estradiol] GO:0033280[response to vitamin D] GO:0034116[positive regulation of heterotypic cell-cell adhesion] GO:0034504[protein localization to nucleus] GO:0035239[tube morphogenesis] GO:0036305[ameloblast differentiation] GO:0042325[regulation of phosphorylation] GO:0042326[negative regulation of phosphorylation] GO:0042475[odontogenesis of dentin-containing tooth] GO:0043065[positive regulation of apoptotic process] GO:0043401[steroid hormone mediated signaling pathway] GO:0043407[negative regulation of MAP kinase activity] GO:0043434[response to peptide hormone] GO:0045665[negative regulation of neuron differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045786[negative regulation of cell cycle] GO:0045839[negative regulation of mitotic nuclear division] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048468[cell development] GO:0048593[camera-type eye morphogenesis] GO:0048596[embryonic camera-type eye morphogenesis] GO:0048646[anatomical structure formation involved in morphogenesis] GO:0048738[cardiac muscle tissue development] GO:0048754[branching morphogenesis of an epithelial tube] GO:0048762[mesenchymal cell differentiation] GO:0048812[neuron projection morphogenesis] GO:0050768[negative regulation of neurogenesis] GO:0051216[cartilage development] GO:0060037[pharyngeal system development] GO:0060272[embryonic skeletal joint morphogenesis] GO:0060391[positive regulation of SMAD protein signal transduction] GO:0060393[regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395[SMAD protein signal transduction] GO:0060411[cardiac septum morphogenesis] GO:0060445[branching involved in salivary gland morphogenesis] GO:0060485[mesenchyme development] GO:0060548[negative regulation of cell death] GO:0060686[negative regulation of prostatic bud formation] GO:0060687[regulation of branching involved in prostate gland morphogenesis] GO:0060710[chorio-allantoic fusion] GO:0061384[heart trabecula morphogenesis] GO:0062023[collagen-containing extracellular matrix] GO:0070487[monocyte aggregation] GO:0070700[BMP receptor binding] GO:0071456[cellular response to hypoxia] GO:0071773[cellular response to BMP stimulus] GO:0072040[negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis] GO:0072125[negative regulation of glomerular mesangial cell proliferation] GO:0072133[metanephric mesenchyme morphogenesis] GO:0072134[nephrogenic mesenchyme morphogenesis] GO:0072136[metanephric mesenchymal cell proliferation involved in metanephros development] GO:0090336[positive regulation of brown fat cell differentiation] GO:1900006[positive regulation of dendrite development] GO:1900106[positive regulation of hyaluranon cable assembly] GO:1901145[mesenchymal cell apoptotic process involved in nephron morphogenesis] GO:1901223[negative regulation of NIK/NF-kappaB signaling] GO:1905069[allantois development] GO:1905312[positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis] GO:2000121[regulation of removal of superoxide radicals]
The Human Protein Atlas project is funded
