GENERAL INFORMATIONi
Gene namei HCK
Synonyms JTK9
Gene descriptioni HCK proto-oncogene, Src family tyrosine kinase
Protein classi Disease related genes
Enzymes
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 20
Cytoband q11.21
Chromosome location (bp) 32052197 - 32101856
Number of transcriptsi 5
Ensembl ENSG00000101336 (version 109)
Entrez gene 3055
HGNC HGNC:4840
UniProt P08631 (UniProt - Evidence at protein level)
neXtProt NX_P08631
GeneCards HCK
Antibodypedia HCK antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS. show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Exocytosis, Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Phagocytosis
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
HCK-202
ENSP00000365012
ENST00000375852
P08631
[Direct mapping] Tyrosine-protein kinase HCK
Show all
J3KPD6
[Direct mapping] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0002376 [immune system process]
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051179 [localization]
GO:0060333 [type II interferon-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 526 aa
59.6 kDa 		No 0
HCK-203
ENSP00000365022
ENST00000375862
P08631
[Direct mapping] Tyrosine-protein kinase HCK
Show all
H0Y3C5
[Direct mapping] Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0002376 [immune system process]
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051179 [localization]
GO:0060333 [type II interferon-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 525 aa
59.5 kDa 		No 0
HCK-206
ENSP00000427757
ENST00000518730
P08631
[Direct mapping] Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0002376 [immune system process]
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051179 [localization]
GO:0060333 [type II interferon-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 504 aa
57.2 kDa 		No 0
HCK-207
ENSP00000429848
ENST00000520553
P08631
[Direct mapping] Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0002376 [immune system process]
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051179 [localization]
GO:0060333 [type II interferon-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 505 aa
57.3 kDa 		No 0
HCK-208
ENSP00000486627
ENST00000629881
P08631
[Direct mapping] Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0002376 [immune system process]
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006887 [exocytosis]
GO:0006909 [phagocytosis]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008360 [regulation of cell shape]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051179 [localization]
GO:0060333 [type II interferon-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 505 aa
57.3 kDa 		No 0

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