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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
p12.2
Chromosome location (bp)
10637684 - 10673999
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling 1,2. May be involved in cell-fate decisions during hematopoiesis 3. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Notch signaling pathway
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Human disease related genes Congenital malformations Congenital malformations of the circulatory system Congenital malformations of the digestive system Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0001525[angiogenesis] GO:0001709[cell fate determination] GO:0001953[negative regulation of cell-matrix adhesion] GO:0001974[blood vessel remodeling] GO:0002011[morphogenesis of an epithelial sheet] GO:0002085[inhibition of neuroepithelial cell differentiation] GO:0002456[T cell mediated immunity] GO:0003180[aortic valve morphogenesis] GO:0003184[pulmonary valve morphogenesis] GO:0003215[cardiac right ventricle morphogenesis] GO:0005112[Notch binding] GO:0005198[structural molecule activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005543[phospholipid binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0007154[cell communication] GO:0007219[Notch signaling pathway] GO:0007275[multicellular organism development] GO:0007399[nervous system development] GO:0008083[growth factor activity] GO:0009887[animal organ morphogenesis] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016324[apical plasma membrane] GO:0022408[negative regulation of cell-cell adhesion] GO:0030097[hemopoiesis] GO:0030182[neuron differentiation] GO:0030216[keratinocyte differentiation] GO:0030336[negative regulation of cell migration] GO:0032495[response to muramyl dipeptide] GO:0032502[developmental process] GO:0035909[aorta morphogenesis] GO:0042127[regulation of cell population proliferation] GO:0042491[inner ear auditory receptor cell differentiation] GO:0043010[camera-type eye development] GO:0045177[apical part of cell] GO:0045445[myoblast differentiation] GO:0045446[endothelial cell differentiation] GO:0045599[negative regulation of fat cell differentiation] GO:0045602[negative regulation of endothelial cell differentiation] GO:0045639[positive regulation of myeloid cell differentiation] GO:0045665[negative regulation of neuron differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045747[positive regulation of Notch signaling pathway] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048839[inner ear development] GO:0050678[regulation of epithelial cell proliferation] GO:0060090[molecular adaptor activity] GO:0060411[cardiac septum morphogenesis] GO:0061073[ciliary body morphogenesis] GO:0061101[neuroendocrine cell differentiation] GO:0061156[pulmonary artery morphogenesis] GO:0061309[cardiac neural crest cell development involved in outflow tract morphogenesis] GO:0061314[Notch signaling involved in heart development] GO:0061444[endocardial cushion cell development] GO:0062043[positive regulation of cardiac epithelial to mesenchymal transition] GO:0072006[nephron development] GO:0072015[podocyte development] GO:0072017[distal tubule development] GO:0072070[loop of Henle development] GO:0097150[neuronal stem cell population maintenance] GO:2000241[regulation of reproductive process] GO:2000737[negative regulation of stem cell differentiation]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of the circulatory system Congenital malformations of the digestive system Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
