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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.23
Chromosome location (bp)
38805697 - 38923024
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function 1. Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation 2. Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells 3,4. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation 5. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 6. Involved in the dephosphorylation of EEF1A1 7....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q96T49 [Direct mapping] Protein phosphatase 1 regulatory inhibitor subunit 16B
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001938[positive regulation of endothelial cell proliferation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005886[plasma membrane] GO:0008157[protein phosphatase 1 binding] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0017020[myosin phosphatase regulator activity] GO:0019888[protein phosphatase regulator activity] GO:0035304[regulation of protein dephosphorylation] GO:0035307[positive regulation of protein dephosphorylation] GO:0035308[negative regulation of protein dephosphorylation] GO:0042995[cell projection] GO:0048471[perinuclear region of cytoplasm] GO:0051489[regulation of filopodium assembly] GO:0061028[establishment of endothelial barrier] GO:1902309[negative regulation of peptidyl-serine dephosphorylation] GO:1903589[positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903670[regulation of sprouting angiogenesis]
Q96T49 [Direct mapping] Protein phosphatase 1 regulatory inhibitor subunit 16B
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938[positive regulation of endothelial cell proliferation] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005886[plasma membrane] GO:0008157[protein phosphatase 1 binding] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0016607[nuclear speck] GO:0017020[myosin phosphatase regulator activity] GO:0019888[protein phosphatase regulator activity] GO:0035304[regulation of protein dephosphorylation] GO:0035307[positive regulation of protein dephosphorylation] GO:0035308[negative regulation of protein dephosphorylation] GO:0042995[cell projection] GO:0048471[perinuclear region of cytoplasm] GO:0051489[regulation of filopodium assembly] GO:0061028[establishment of endothelial barrier] GO:1902309[negative regulation of peptidyl-serine dephosphorylation] GO:1903589[positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903670[regulation of sprouting angiogenesis]
The Human Protein Atlas project is funded
