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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
Chromosome location (bp)
9463320 - 9741037
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units 1. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0007605[sensory perception of sound] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016575[histone deacetylation] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0042393[histone binding] GO:0042802[identical protein binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050821[protein stabilization] GO:0072686[mitotic spindle] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0007605[sensory perception of sound] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016575[histone deacetylation] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0042393[histone binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050821[protein stabilization] GO:0072686[mitotic spindle] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding]
C9JCW3 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Protein evidence (Ezkurdia et al 2014)
O60907 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0007605[sensory perception of sound] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016575[histone deacetylation] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0042393[histone binding] GO:0042802[identical protein binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050821[protein stabilization] GO:0072686[mitotic spindle] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding]
C9J5F9 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0007605[sensory perception of sound] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016575[histone deacetylation] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0042393[histone binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050821[protein stabilization] GO:0072686[mitotic spindle] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0007605[sensory perception of sound] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016575[histone deacetylation] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0042393[histone binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050821[protein stabilization] GO:0072686[mitotic spindle] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000976[transcription cis-regulatory region binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006508[proteolysis] GO:0007605[sensory perception of sound] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016575[histone deacetylation] GO:0017053[transcription repressor complex] GO:0019904[protein domain specific binding] GO:0042393[histone binding] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050821[protein stabilization] GO:0072686[mitotic spindle] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:0140297[DNA-binding transcription factor binding]
A0A2R8YFW3 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Protein evidence (Ezkurdia et al 2014)
A0A2R8Y757 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Protein evidence (Ezkurdia et al 2014)
A0A804HJZ5 [Direct mapping] F-box-like/WD repeat-containing protein TBL1X
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Thyroid gland diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
