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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
N-alpha-acetyltransferase 10, NatA catalytic subunit
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q28
Chromosome location (bp)
153929225 - 153935080
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity 1,2,3,4,5,6,7,8,9. Acetylates amino termini that are devoid of initiator methionine 10. The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation 11. Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration 12. Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development 13. Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX 14. Acetylates HIST1H4A 15. Acts as a negative regulator of sister chromatid cohesion during mitosis 16....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Acyltransferase, Transferase
Gene summary (Entrez)i
Useful information about the gene from Entrez
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006473[protein acetylation] GO:0006474[N-terminal protein amino acid acetylation] GO:0006475[internal protein amino acid acetylation] GO:0008080[N-acetyltransferase activity] GO:0016020[membrane] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0031415[NatA complex] GO:0043022[ribosome binding] GO:0051276[chromosome organization] GO:1990189[peptide-serine-alpha-N-acetyltransferase activity] GO:1990190[peptide-glutamate-alpha-N-acetyltransferase activity] GO:2000719[negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric]
C9JN83 [Direct mapping] N-terminal amino-acid N(alpha)-acetyltransferase NatA
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
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GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0006474[N-terminal protein amino acid acetylation] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0031415[NatA complex]
F8W808 [Direct mapping] N-terminal amino-acid N(alpha)-acetyltransferase NatA
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
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GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0006474[N-terminal protein amino acid acetylation] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0031415[NatA complex]
A8MWP7 [Direct mapping] N-terminal amino-acid N(alpha)-acetyltransferase NatA
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0006474[N-terminal protein amino acid acetylation] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0031415[NatA complex]
C9JW55 [Direct mapping] N-terminal amino-acid N(alpha)-acetyltransferase NatA
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital malformations Congenital malformations of eye Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0006474[N-terminal protein amino acid acetylation] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0031415[NatA complex]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004596[peptide alpha-N-acetyltransferase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006473[protein acetylation] GO:0006474[N-terminal protein amino acid acetylation] GO:0006475[internal protein amino acid acetylation] GO:0008080[N-acetyltransferase activity] GO:0016020[membrane] GO:0016407[acetyltransferase activity] GO:0016740[transferase activity] GO:0016746[acyltransferase activity] GO:0016747[acyltransferase activity, transferring groups other than amino-acyl groups] GO:0031415[NatA complex] GO:0043022[ribosome binding] GO:0051276[chromosome organization] GO:1990189[peptide-serine-alpha-N-acetyltransferase activity] GO:1990190[peptide-glutamate-alpha-N-acetyltransferase activity] GO:2000719[negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric]
The Human Protein Atlas project is funded
