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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.2
Chromosome location (bp)
11574653 - 11579993
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5
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A0A024R7F8 [Target identity:100%; Query identity:100%] Tartrate-resistant acid phosphatase type 5
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Enzymes ENZYME proteins Hydrolases Metabolic proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5
Show all
A0A024R7F8 [Target identity:100%; Query identity:100%] Tartrate-resistant acid phosphatase type 5
Show all
Enzymes ENZYME proteins Hydrolases Metabolic proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5
Show all
A0A024R7F8 [Target identity:100%; Query identity:100%] Tartrate-resistant acid phosphatase type 5
Show all
Enzymes ENZYME proteins Hydrolases Metabolic proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003993[acid phosphatase activity] GO:0005764[lysosome] GO:0005829[cytosol] GO:0006809[nitric oxide biosynthetic process] GO:0008198[ferrous iron binding] GO:0008199[ferric iron binding] GO:0010936[negative regulation of macrophage cytokine production] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0032496[response to lipopolysaccharide] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032695[negative regulation of interleukin-12 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032929[negative regulation of superoxide anion generation] GO:0034097[response to cytokine] GO:0042554[superoxide anion generation] GO:0045019[negative regulation of nitric oxide biosynthetic process] GO:0045453[bone resorption] GO:0046872[metal ion binding] GO:0050728[negative regulation of inflammatory response] GO:0050830[defense response to Gram-positive bacterium] GO:0060349[bone morphogenesis]
A0A024R7F8 [Target identity:100%; Query identity:100%] Tartrate-resistant acid phosphatase type 5
Show all
Metabolic proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
