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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
13
Cytoband
q12.3
Chromosome location (bp)
28300346 - 28495145
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 1....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Chemotaxis, Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002244[hematopoietic progenitor cell differentiation] GO:0002548[monocyte chemotaxis] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005021[vascular endothelial growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006935[chemotaxis] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0015629[actin cytoskeleton] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0036323[vascular endothelial growth factor receptor-1 signaling pathway] GO:0036332[placental growth factor receptor activity] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043408[regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048514[blood vessel morphogenesis] GO:0048598[embryonic morphogenesis] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990384[hyaloid vascular plexus regression]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0002244[hematopoietic progenitor cell differentiation] GO:0002548[monocyte chemotaxis] GO:0004672[protein kinase activity] GO:0004713[protein tyrosine kinase activity] GO:0004714[transmembrane receptor protein tyrosine kinase activity] GO:0005021[vascular endothelial growth factor receptor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005768[endosome] GO:0005886[plasma membrane] GO:0005887[integral component of plasma membrane] GO:0005925[focal adhesion] GO:0006468[protein phosphorylation] GO:0006935[chemotaxis] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0008284[positive regulation of cell population proliferation] GO:0010863[positive regulation of phospholipase C activity] GO:0014068[positive regulation of phosphatidylinositol 3-kinase signaling] GO:0015629[actin cytoskeleton] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016477[cell migration] GO:0016740[transferase activity] GO:0018108[peptidyl-tyrosine phosphorylation] GO:0019838[growth factor binding] GO:0030154[cell differentiation] GO:0030335[positive regulation of cell migration] GO:0031401[positive regulation of protein modification process] GO:0033674[positive regulation of kinase activity] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0036323[vascular endothelial growth factor receptor-1 signaling pathway] GO:0036332[placental growth factor receptor activity] GO:0038084[vascular endothelial growth factor signaling pathway] GO:0043235[receptor complex] GO:0043406[positive regulation of MAP kinase activity] GO:0043408[regulation of MAPK cascade] GO:0043410[positive regulation of MAPK cascade] GO:0043552[positive regulation of phosphatidylinositol 3-kinase activity] GO:0045766[positive regulation of angiogenesis] GO:0046777[protein autophosphorylation] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0048514[blood vessel morphogenesis] GO:0048598[embryonic morphogenesis] GO:1905563[negative regulation of vascular endothelial cell proliferation] GO:1990384[hyaloid vascular plexus regression]
The Human Protein Atlas project is funded
