GENERAL INFORMATIONi
Gene namei MAPK3
Synonyms ERK1, p44erk1, p44mapk, PRKM3
Gene descriptioni Mitogen-activated protein kinase 3
Protein classi Cancer-related genes
Enzymes
FDA approved drug targets
RAS pathway related proteins
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 16
Cytoband p11.2
Chromosome location (bp) 30114105 - 30123506
Number of transcriptsi 8
Ensembl ENSG00000102882 (version 109)
Entrez gene 5595
HGNC HGNC:6877
UniProt P27361 (UniProt - Evidence at protein level)
neXtProt NX_P27361
GeneCards MAPK3
Antibodypedia MAPK3 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway 1. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DEPTOR, FRS2 or GRB10) 2. Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. show less
Molecular function (UniProt)i Kinase, Serine/threonine-protein kinase, Transferase
Biological process (UniProt)i Apoptosis, Cell cycle, Host-virus interaction
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MAPK3-201
ENSP00000263025
ENST00000263025
P27361
[Direct mapping] Mitogen-activated protein kinase 3
Show all
L7RXH5
[Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006351 [DNA-templated transcription]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019233 [sensory perception of pain]
GO:0019902 [phosphatase binding]
GO:0030278 [regulation of ossification]
GO:0030509 [BMP signaling pathway]
GO:0030641 [regulation of cellular pH]
GO:0030878 [thyroid gland development]
GO:0031143 [pseudopodium]
GO:0031281 [positive regulation of cyclase activity]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032496 [response to lipopolysaccharide]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042221 [response to chemical]
GO:0042473 [outer ear morphogenesis]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043330 [response to exogenous dsRNA]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048538 [thymus development]
GO:0050804 [modulation of chemical synaptic transmission]
GO:0051090 [regulation of DNA-binding transcription factor activity]
GO:0051216 [cartilage development]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060324 [face development]
GO:0060425 [lung morphogenesis]
GO:0060440 [trachea formation]
GO:0061308 [cardiac neural crest cell development involved in heart development]
GO:0070161 [anchoring junction]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070849 [response to epidermal growth factor]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:0098792 [xenophagy]
GO:0098978 [glutamatergic synapse]
GO:0106310 [protein serine kinase activity]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140297 [DNA-binding transcription factor binding]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:1904417 [positive regulation of xenophagy]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000657 [negative regulation of apolipoprotein binding]
Show all
 379 aa
43.1 kDa 		No 0
MAPK3-202
ENSP00000327293
ENST00000322266
P27361
[Direct mapping] Mitogen-activated protein kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019902 [phosphatase binding]
GO:0030509 [BMP signaling pathway]
GO:0031281 [positive regulation of cyclase activity]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042221 [response to chemical]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070849 [response to epidermal growth factor]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:0106310 [protein serine kinase activity]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140297 [DNA-binding transcription factor binding]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 335 aa
38.3 kDa 		No 0
MAPK3-203
ENSP00000378625
ENST00000395199
P27361
[Direct mapping] Mitogen-activated protein kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019902 [phosphatase binding]
GO:0030509 [BMP signaling pathway]
GO:0031281 [positive regulation of cyclase activity]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042221 [response to chemical]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070849 [response to epidermal growth factor]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:0106310 [protein serine kinase activity]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140297 [DNA-binding transcription factor binding]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 357 aa
40.1 kDa 		No 0
MAPK3-204
ENSP00000378626
ENST00000395200
E9PBK7
[Direct mapping] Mitogen-activated protein kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0042221 [response to chemical]
GO:0051493 [regulation of cytoskeleton organization]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:0106310 [protein serine kinase activity]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 311 aa
36 kDa 		No 0
MAPK3-205
ENSP00000378628
ENST00000395202
P27361
[Direct mapping] Mitogen-activated protein kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007166 [cell surface receptor signaling pathway]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0019902 [phosphatase binding]
GO:0030509 [BMP signaling pathway]
GO:0031281 [positive regulation of cyclase activity]
GO:0032212 [positive regulation of telomere maintenance via telomerase]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0034198 [cellular response to amino acid starvation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042221 [response to chemical]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0051403 [stress-activated MAPK cascade]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051973 [positive regulation of telomerase activity]
GO:0070161 [anchoring junction]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070849 [response to epidermal growth factor]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071276 [cellular response to cadmium ion]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:0106310 [protein serine kinase activity]
GO:0120041 [positive regulation of macrophage proliferation]
GO:0140297 [DNA-binding transcription factor binding]
GO:1903351 [cellular response to dopamine]
GO:1904355 [positive regulation of telomere capping]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 335 aa
38.3 kDa 		No 0
MAPK3-209
ENSP00000432292
ENST00000478356
E9PRH7
[Direct mapping] Mitogen-activated protein kinase 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0042221 [response to chemical]
GO:0051493 [regulation of cytoskeleton organization]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 136 aa
15.8 kDa 		No 0
MAPK3-210
ENSP00000433639
ENST00000481230
H0YDH9
[Direct mapping] Mitogen-activated protein kinase 3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0042221 [response to chemical]
GO:0051493 [regulation of cytoskeleton organization]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 87 aa
10.2 kDa 		No 0
MAPK3-212
ENSP00000432742
ENST00000484663
B3KR49
[Direct mapping] Mitogen-activated protein kinase 3; Mitogen-activated protein kinase 3, isoform CRA_b; cDNA FLJ33690 fis, clone BRAWH2002967, highly similar to Mitogen-activated protein kinase 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0032872 [regulation of stress-activated MAPK cascade]
GO:0042221 [response to chemical]
GO:0051493 [regulation of cytoskeleton organization]
GO:0072584 [caveolin-mediated endocytosis]
GO:0090170 [regulation of Golgi inheritance]
GO:2000641 [regulation of early endosome to late endosome transport]
Show all
 265 aa
30.6 kDa 		No 0

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