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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
TATA-box binding protein associated factor, RNA polymerase I subunit C
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q24.1
Chromosome location (bp)
84177847 - 84187070
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q15572 [Direct mapping] TATA box-binding protein-associated factor RNA polymerase I subunit C
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006360[transcription by RNA polymerase I] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II]
Q15572 [Direct mapping] TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006360[transcription by RNA polymerase I] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II]
Q15572 [Direct mapping] TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005668[RNA polymerase transcription factor SL1 complex] GO:0005730[nucleolus] GO:0006360[transcription by RNA polymerase I] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II]
Q15572 [Direct mapping] TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006360[transcription by RNA polymerase I] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II]
Q15572 [Direct mapping] TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001164[RNA polymerase I core promoter sequence-specific DNA binding] GO:0001181[RNA polymerase I general transcription initiation factor activity] GO:0001188[RNA polymerase I preinitiation complex assembly] GO:0001650[fibrillar center] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0006360[transcription by RNA polymerase I] GO:0006361[transcription initiation at RNA polymerase I promoter] GO:0006366[transcription by RNA polymerase II]
The Human Protein Atlas project is funded
