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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q24.1
Chromosome location (bp)
86510527 - 86515422
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Probable transcription activator for a number of lung-specific genes....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Helix-turn-helix domains Disease related genes Human disease related genes Respiratory diseases Lung diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001568[blood vessel development] GO:0001570[vasculogenesis] GO:0001701[in utero embryonic development] GO:0001756[somitogenesis] GO:0001763[morphogenesis of a branching structure] GO:0002053[positive regulation of mesenchymal cell proliferation] GO:0003197[endocardial cushion development] GO:0003214[cardiac left ventricle morphogenesis] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007224[smoothened signaling pathway] GO:0007368[determination of left/right symmetry] GO:0007494[midgut development] GO:0007498[mesoderm development] GO:0007507[heart development] GO:0009887[animal organ morphogenesis] GO:0010811[positive regulation of cell-substrate adhesion] GO:0014822[detection of wounding] GO:0030198[extracellular matrix organization] GO:0030323[respiratory tube development] GO:0030324[lung development] GO:0030335[positive regulation of cell migration] GO:0031016[pancreas development] GO:0043305[negative regulation of mast cell degranulation] GO:0043565[sequence-specific DNA binding] GO:0045198[establishment of epithelial cell apical/basal polarity] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048286[lung alveolus development] GO:0048333[mesodermal cell differentiation] GO:0048371[lateral mesodermal cell differentiation] GO:0048557[embryonic digestive tract morphogenesis] GO:0048565[digestive tract development] GO:0048566[embryonic digestive tract development] GO:0048613[embryonic ectodermal digestive tract morphogenesis] GO:0048617[embryonic foregut morphogenesis] GO:0050728[negative regulation of inflammatory response] GO:0051145[smooth muscle cell differentiation] GO:0060425[lung morphogenesis] GO:0060426[lung vasculature development] GO:0060438[trachea development] GO:0060441[epithelial tube branching involved in lung morphogenesis] GO:0060461[right lung morphogenesis] GO:0060463[lung lobe morphogenesis] GO:0060841[venous blood vessel development] GO:0061030[epithelial cell differentiation involved in mammary gland alveolus development] GO:0071345[cellular response to cytokine stimulus] GO:0071407[cellular response to organic cyclic compound] GO:0072189[ureter development] GO:0090131[mesenchyme migration] GO:0097070[ductus arteriosus closure] GO:0098609[cell-cell adhesion]
The Human Protein Atlas project is funded
