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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.32
Chromosome location (bp)
46674275 - 46717127
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion 1,2,3,4,5,6,7,8,9,10,11. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is phosphorylated at Tyr-438 and Tyr-717 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B 12,13. In response to the activation of the gastrin receptor CCKBR, is phosphorylated at Ser-244 by CSNK1D and CSNK1E, translocates to the nucleus, phosphorylates HDAC7, leading to nuclear export of HDAC7 and inhibition of HDAC7 transcriptional repression of NR4A1/NUR77 14. Upon TCR stimulation, is activated independently of ZAP70, translocates from the cytoplasm to the nucleus and is required for interleukin-2 (IL2) promoter up-regulation 15. During adaptive immune responses, is required in peripheral T-lymphocytes for the production of the effector cytokines IL2 and IFNG after TCR engagement and for optimal induction of antibody responses to antigens (By similarity). In epithelial cells stimulated with lysophosphatidic acid (LPA), is activated through a PKC-dependent pathway and mediates LPA-stimulated interleukin-8 (IL8) secretion via a NF-kappa-B-dependent pathway 16. During TCR-induced T-cell activation, interacts with and is activated by the tyrosine kinase LCK, which results in the activation of the NFAT transcription factors 17. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane and in polarized cells is involved in the transport of proteins from the TGN to the basolateral membrane 18. Plays an important role in endothelial cell proliferation and migration prior to angiogenesis, partly through modulation of the expression of KDR/VEGFR2 and FGFR1, two key growth factor receptors involved in angiogenesis 19. In secretory pathway, is required for the release of chromogranin-A (CHGA)-containing secretory granules from the TGN 20. Downstream of PRKCA, plays important roles in angiotensin-2-induced monocyte adhesion to endothelial cells 21. Plays a regulatory role in angiogenesis and tumor growth by phosphorylating a downstream mediator CIB1 isoform 2, resulting in vascular endothelial growth factor A (VEGFA) secretion 22....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007155[cell adhesion] GO:0010595[positive regulation of endothelial cell migration] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030148[sphingolipid biosynthetic process] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032743[positive regulation of interleukin-2 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032793[positive regulation of CREB transcription factor activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035556[intracellular signal transduction] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0036211[protein modification process] GO:0038033[positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045743[positive regulation of fibroblast growth factor receptor signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061154[endothelial tube morphogenesis] GO:0070232[regulation of T cell apoptotic process] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0089700[protein kinase D signaling] GO:0106310[protein serine kinase activity] GO:1901727[positive regulation of histone deacetylase activity] GO:1902533[positive regulation of intracellular signal transduction] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001028[positive regulation of endothelial cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007155[cell adhesion] GO:0010595[positive regulation of endothelial cell migration] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030148[sphingolipid biosynthetic process] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032743[positive regulation of interleukin-2 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032793[positive regulation of CREB transcription factor activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035556[intracellular signal transduction] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0036211[protein modification process] GO:0038033[positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045743[positive regulation of fibroblast growth factor receptor signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061154[endothelial tube morphogenesis] GO:0070232[regulation of T cell apoptotic process] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0089700[protein kinase D signaling] GO:0106310[protein serine kinase activity] GO:1901727[positive regulation of histone deacetylase activity] GO:1902533[positive regulation of intracellular signal transduction] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001028[positive regulation of endothelial cell chemotaxis]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001525[angiogenesis] GO:0001938[positive regulation of endothelial cell proliferation] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004697[protein kinase C activity] GO:0004698[calcium-dependent protein kinase C activity] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007155[cell adhesion] GO:0010595[positive regulation of endothelial cell migration] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0030148[sphingolipid biosynthetic process] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032743[positive regulation of interleukin-2 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032793[positive regulation of CREB transcription factor activity] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0035556[intracellular signal transduction] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0036211[protein modification process] GO:0038033[positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0045743[positive regulation of fibroblast growth factor receptor signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046777[protein autophosphorylation] GO:0046872[metal ion binding] GO:0048010[vascular endothelial growth factor receptor signaling pathway] GO:0050852[T cell receptor signaling pathway] GO:0050862[positive regulation of T cell receptor signaling pathway] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0061154[endothelial tube morphogenesis] GO:0070232[regulation of T cell apoptotic process] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0089700[protein kinase D signaling] GO:0106310[protein serine kinase activity] GO:1901727[positive regulation of histone deacetylase activity] GO:1902533[positive regulation of intracellular signal transduction] GO:2000573[positive regulation of DNA biosynthetic process] GO:2001028[positive regulation of endothelial cell chemotaxis]
The Human Protein Atlas project is funded
