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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.33
Chromosome location (bp)
48180770 - 48255946
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inflammasome sensor, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis of CD4(+) T-cells and macrophages 1,2,3,4,5,6,7,8. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation 9,10,11,12. Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as HIV-1 protease activity or Val-boroPro inhibitor, and mediates CARD8 inflammasome activation 13,14,15. In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the CARD8 inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis 16,17,18,19,20. Ability to sense HIV-1 protease activity leads to the clearance of latent HIV-1 in patient CD4(+) T-cells after viral reactivation; in contrast, HIV-1 can evade CARD8-sensing when its protease remains inactive in infected cells prior to viral budding 21. Also acts as a negative regulator of the NLRP3 inflammasome 22. May also act as an inhibitor of NF-kappa-B activation 23,24....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
E5RGG3 [Direct mapping] Caspase recruitment domain-containing protein 8
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
E5RJG3 [Direct mapping] Caspase recruitment domain-containing protein 8
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Q9Y2G2 [Direct mapping] Caspase recruitment domain-containing protein 8 Caspase recruitment domain-containing protein 8, C-terminus Caspase recruitment domain-containing protein 8, N-terminus
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376[immune system process] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006508[proteolysis] GO:0006919[activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008656[cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0012501[programmed cell death] GO:0016787[hydrolase activity] GO:0031665[negative regulation of lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032089[NACHT domain binding] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032991[protein-containing complex] GO:0038187[pattern recognition receptor activity] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0050700[CARD domain binding] GO:0051607[defense response to virus] GO:0061702[inflammasome complex] GO:0072559[NLRP3 inflammasome complex] GO:0097264[self proteolysis] GO:0097340[inhibition of cysteine-type endopeptidase activity] GO:0140374[antiviral innate immune response] GO:0140608[cysteine-type endopeptidase activator activity] GO:1900226[negative regulation of NLRP3 inflammasome complex assembly]
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