We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q36.3
Chromosome location (bp)
157335381 - 157417439
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 1,2. Plays an indispensable role in the organization of KRT8/KRT18 filaments 3. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin 4,5. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins 6,7. Also reduces cellular toxicity and caspase-3 activity 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O75190 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671[ATPase activator activity] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006457[protein folding] GO:0016020[membrane] GO:0030018[Z disc] GO:0030036[actin cytoskeleton organization] GO:0030198[extracellular matrix organization] GO:0030544[Hsp70 protein binding] GO:0031072[heat shock protein binding] GO:0032880[regulation of protein localization] GO:0034504[protein localization to nucleus] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044183[protein folding chaperone] GO:0045109[intermediate filament organization] GO:0045892[negative regulation of DNA-templated transcription] GO:0048471[perinuclear region of cytoplasm] GO:0051082[unfolded protein binding] GO:0051087[chaperone binding] GO:0060710[chorio-allantoic fusion] GO:0060715[syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0060717[chorion development] GO:0061077[chaperone-mediated protein folding] GO:0090084[negative regulation of inclusion body assembly] GO:1900034[regulation of cellular response to heat]
C9JDX6 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
C9J2C4 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
O75190 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Musculoskeletal diseases Muscular diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
C9JB42 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
C9JN01 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
C9J2P2 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
E9PH18 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
C9JDR7 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
A0A0J9YX62 [Direct mapping] DnaJ homolog subfamily B member 6
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Musculoskeletal diseases Muscular diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
