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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p12.1
Chromosome location (bp)
50590063 - 50793462
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032868[response to insulin] GO:0032991[protein-containing complex] GO:0042327[positive regulation of phosphorylation] GO:0045719[negative regulation of glycogen biosynthetic process] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0010467[gene expression] GO:0030159[signaling receptor complex adaptor activity] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030674[protein-macromolecule adaptor activity] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032868[response to insulin] GO:0032991[protein-containing complex] GO:0042326[negative regulation of phosphorylation] GO:0042327[positive regulation of phosphorylation] GO:0045719[negative regulation of glycogen biosynthetic process] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0070371[ERK1 and ERK2 cascade] GO:0120162[positive regulation of cold-induced thermogenesis] GO:1904738[vascular associated smooth muscle cell migration]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
Q13322 [Direct mapping] Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158[insulin receptor binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0008286[insulin receptor signaling pathway] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030949[positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0032991[protein-containing complex] GO:0042802[identical protein binding] GO:0046325[negative regulation of glucose import] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0120162[positive regulation of cold-induced thermogenesis]
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