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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q11.23
Chromosome location (bp)
76302673 - 76304295
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state 1,2. Plays a role in stress resistance and actin organization 3. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins 4....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Stress response
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
V9HW43 [Target identity:100%; Query identity:100%] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000502[proteasome complex] GO:0001533[cornified envelope] GO:0001895[retina homeostasis] GO:0001932[regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0005080[protein kinase C binding] GO:0005515[protein binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005819[spindle] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006446[regulation of translational initiation] GO:0006469[negative regulation of protein kinase activity] GO:0006986[response to unfolded protein] GO:0008426[protein kinase C inhibitor activity] GO:0009408[response to heat] GO:0009615[response to virus] GO:0010506[regulation of autophagy] GO:0019901[protein kinase binding] GO:0030018[Z disc] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0035556[intracellular signal transduction] GO:0035924[cellular response to vascular endothelial growth factor stimulus] GO:0038033[positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0042026[protein refolding] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043066[negative regulation of apoptotic process] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130[ubiquitin binding] GO:0043292[contractile fiber] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0044183[protein folding chaperone] GO:0045766[positive regulation of angiogenesis] GO:0051082[unfolded protein binding] GO:0061077[chaperone-mediated protein folding] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:0099641[anterograde axonal protein transport] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1904115[axon cytoplasm] GO:2001028[positive regulation of endothelial cell chemotaxis] GO:2001234[negative regulation of apoptotic signaling pathway]
C9J3N8 [Direct mapping] Heat shock protein beta-1; Putative heat shock protein family B member 1 isoform
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PHJ6 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PHA6 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PF43 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PFK8 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PH65 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PGY2 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PHJ6 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
A0A6Q8PGK1 [Direct mapping] Heat shock protein beta-1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
