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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Enhancer of zeste 2 polycomb repressive complex 2 subunit
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q36.1
Chromosome location (bp)
148807257 - 148884321
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 1,2. Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
S-adenosyl-L-methionine
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082[G1/S transition of mitotic cell cycle] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0001222[transcription corepressor binding] GO:0001932[regulation of protein phosphorylation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005677[chromatin silencing complex] GO:0005721[pericentric heterochromatin] GO:0005737[cytoplasm] GO:0006306[DNA methylation] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008168[methyltransferase activity] GO:0008284[positive regulation of cell population proliferation] GO:0009913[epidermal cell differentiation] GO:0010468[regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0014013[regulation of gliogenesis] GO:0014834[skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014898[cardiac muscle hypertrophy in response to stress] GO:0016279[protein-lysine N-methyltransferase activity] GO:0016570[histone modification] GO:0016740[transferase activity] GO:0018024[histone-lysine N-methyltransferase activity] GO:0021695[cerebellar cortex development] GO:0021766[hippocampus development] GO:0030097[hemopoiesis] GO:0030183[B cell differentiation] GO:0030216[keratinocyte differentiation] GO:0031490[chromatin DNA binding] GO:0031507[heterochromatin formation] GO:0031509[subtelomeric heterochromatin formation] GO:0032259[methylation] GO:0032355[response to estradiol] GO:0034244[negative regulation of transcription elongation by RNA polymerase II] GO:0035098[ESC/E(Z) complex] GO:0035984[cellular response to trichostatin A] GO:0036333[hepatocyte homeostasis] GO:0042054[histone methyltransferase activity] GO:0042127[regulation of cell population proliferation] GO:0042752[regulation of circadian rhythm] GO:0043021[ribonucleoprotein complex binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043547[positive regulation of GTPase activity] GO:0043565[sequence-specific DNA binding] GO:0045120[pronucleus] GO:0045202[synapse] GO:0045605[negative regulation of epidermal cell differentiation] GO:0045617[negative regulation of keratinocyte differentiation] GO:0045814[negative regulation of gene expression, epigenetic] GO:0045892[negative regulation of DNA-templated transcription] GO:0046976[histone methyltransferase activity (H3-K27 specific)] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048511[rhythmic process] GO:0048863[stem cell differentiation] GO:0050767[regulation of neurogenesis] GO:0051154[negative regulation of striated muscle cell differentiation] GO:0051932[synaptic transmission, GABAergic] GO:0070301[cellular response to hydrogen peroxide] GO:0070314[G1 to G0 transition] GO:0070734[histone H3-K27 methylation] GO:0070878[primary miRNA binding] GO:0071168[protein localization to chromatin] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0097421[liver regeneration] GO:0098532[histone H3-K27 trimethylation] GO:0106222[lncRNA binding] GO:0140718[facultative heterochromatin formation] GO:0140951[] GO:1900006[positive regulation of dendrite development] GO:1900016[negative regulation of cytokine production involved in inflammatory response] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1904772[response to tetrachloromethane] GO:1990841[promoter-specific chromatin binding] GO:2000134[negative regulation of G1/S transition of mitotic cell cycle] GO:2000737[negative regulation of stem cell differentiation]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008168[methyltransferase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016279[protein-lysine N-methyltransferase activity] GO:0016740[transferase activity] GO:0018024[histone-lysine N-methyltransferase activity] GO:0031490[chromatin DNA binding] GO:0031507[heterochromatin formation] GO:0031509[subtelomeric heterochromatin formation] GO:0032259[methylation] GO:0035098[ESC/E(Z) complex] GO:0042054[histone methyltransferase activity] GO:0042752[regulation of circadian rhythm] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045202[synapse] GO:0045814[negative regulation of gene expression, epigenetic] GO:0045892[negative regulation of DNA-templated transcription] GO:0046976[histone methyltransferase activity (H3-K27 specific)] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048511[rhythmic process] GO:0070734[histone H3-K27 methylation] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0098532[histone H3-K27 trimethylation] GO:0140951[] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1990841[promoter-specific chromatin binding]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008168[methyltransferase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016279[protein-lysine N-methyltransferase activity] GO:0016740[transferase activity] GO:0018024[histone-lysine N-methyltransferase activity] GO:0031490[chromatin DNA binding] GO:0031507[heterochromatin formation] GO:0031509[subtelomeric heterochromatin formation] GO:0032259[methylation] GO:0035098[ESC/E(Z) complex] GO:0042054[histone methyltransferase activity] GO:0042752[regulation of circadian rhythm] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045202[synapse] GO:0045814[negative regulation of gene expression, epigenetic] GO:0045892[negative regulation of DNA-templated transcription] GO:0046976[histone methyltransferase activity (H3-K27 specific)] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048511[rhythmic process] GO:0070734[histone H3-K27 methylation] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0098532[histone H3-K27 trimethylation] GO:0140951[] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1990841[promoter-specific chromatin binding]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008168[methyltransferase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016279[protein-lysine N-methyltransferase activity] GO:0016740[transferase activity] GO:0018024[histone-lysine N-methyltransferase activity] GO:0031490[chromatin DNA binding] GO:0031507[heterochromatin formation] GO:0031509[subtelomeric heterochromatin formation] GO:0032259[methylation] GO:0035098[ESC/E(Z) complex] GO:0042054[histone methyltransferase activity] GO:0042752[regulation of circadian rhythm] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045202[synapse] GO:0045814[negative regulation of gene expression, epigenetic] GO:0045892[negative regulation of DNA-templated transcription] GO:0046976[histone methyltransferase activity (H3-K27 specific)] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048511[rhythmic process] GO:0070734[histone H3-K27 methylation] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0098532[histone H3-K27 trimethylation] GO:0140951[] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1990841[promoter-specific chromatin binding]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008168[methyltransferase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016279[protein-lysine N-methyltransferase activity] GO:0016740[transferase activity] GO:0018024[histone-lysine N-methyltransferase activity] GO:0031490[chromatin DNA binding] GO:0031507[heterochromatin formation] GO:0031509[subtelomeric heterochromatin formation] GO:0032259[methylation] GO:0035098[ESC/E(Z) complex] GO:0042054[histone methyltransferase activity] GO:0042752[regulation of circadian rhythm] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045202[synapse] GO:0045814[negative regulation of gene expression, epigenetic] GO:0045892[negative regulation of DNA-templated transcription] GO:0046976[histone methyltransferase activity (H3-K27 specific)] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048511[rhythmic process] GO:0070734[histone H3-K27 methylation] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0098532[histone H3-K27 trimethylation] GO:0140951[] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1990841[promoter-specific chromatin binding]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0001222[transcription corepressor binding] GO:0003682[chromatin binding] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006355[regulation of DNA-templated transcription] GO:0008168[methyltransferase activity] GO:0008284[positive regulation of cell population proliferation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0016279[protein-lysine N-methyltransferase activity] GO:0016740[transferase activity] GO:0018024[histone-lysine N-methyltransferase activity] GO:0031490[chromatin DNA binding] GO:0031507[heterochromatin formation] GO:0031509[subtelomeric heterochromatin formation] GO:0032259[methylation] GO:0035098[ESC/E(Z) complex] GO:0042054[histone methyltransferase activity] GO:0042752[regulation of circadian rhythm] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045202[synapse] GO:0045814[negative regulation of gene expression, epigenetic] GO:0045892[negative regulation of DNA-templated transcription] GO:0046976[histone methyltransferase activity (H3-K27 specific)] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048511[rhythmic process] GO:0070734[histone H3-K27 methylation] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0098532[histone H3-K27 trimethylation] GO:0140951[] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1990841[promoter-specific chromatin binding]
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