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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Protein kinase AMP-activated non-catalytic subunit gamma 2
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q36.1
Chromosome location (bp)
151556124 - 151877125
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism 1,2. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation 3,4. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators 5,6. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin 7,8. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits 9,10. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit 11,12. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive 13,14....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004679[AMP-activated protein kinase activity] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
Q9UGJ0 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
Q9UGJ0 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
E9PGP6 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
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GO:0032559[adenyl ribonucleotide binding] GO:0071900[regulation of protein serine/threonine kinase activity]
A0A494C068 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032559[adenyl ribonucleotide binding] GO:0071900[regulation of protein serine/threonine kinase activity]
Q9UGJ0 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
A0A494C1K7 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032559[adenyl ribonucleotide binding] GO:0071900[regulation of protein serine/threonine kinase activity]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005977[glycogen metabolic process] GO:0006110[regulation of glycolytic process] GO:0006468[protein phosphorylation] GO:0006469[negative regulation of protein kinase activity] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006754[ATP biosynthetic process] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0008607[phosphorylase kinase regulator activity] GO:0010800[positive regulation of peptidyl-threonine phosphorylation] GO:0016126[sterol biosynthetic process] GO:0016208[AMP binding] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0019217[regulation of fatty acid metabolic process] GO:0019887[protein kinase regulator activity] GO:0019901[protein kinase binding] GO:0030295[protein kinase activator activity] GO:0031588[nucleotide-activated protein kinase complex] GO:0031669[cellular response to nutrient levels] GO:0032559[adenyl ribonucleotide binding] GO:0035556[intracellular signal transduction] GO:0042149[cellular response to glucose starvation] GO:0043531[ADP binding] GO:0045860[positive regulation of protein kinase activity] GO:0046320[regulation of fatty acid oxidation] GO:0046324[regulation of glucose import] GO:0050790[regulation of catalytic activity] GO:0071900[regulation of protein serine/threonine kinase activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
A0A494C155 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
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GO:0032559[adenyl ribonucleotide binding] GO:0071900[regulation of protein serine/threonine kinase activity]
A0A494C188 [Direct mapping] 5'-AMP-activated protein kinase subunit gamma-2
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Congenital disorders of metabolism Congenital disorders of carbohydrate metabolism Protein evidence (Ezkurdia et al 2014)
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GO:0032559[adenyl ribonucleotide binding] GO:0071900[regulation of protein serine/threonine kinase activity]
The Human Protein Atlas project is funded
