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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p24.1
Chromosome location (bp)
6720863 - 7175648
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Dioxygenase, Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0019899[enzyme binding] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0033169[histone H3-K9 demethylation] GO:0043229[intracellular organelle] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0051213[dioxygenase activity] GO:0051864[histone H3-methyl-lysine-36 demethylase activity] GO:0060765[regulation of androgen receptor signaling pathway] GO:0070076[histone lysine demethylation] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0001825[blastocyst formation] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005721[pericentric heterochromatin] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0010468[regulation of gene expression] GO:0016491[oxidoreductase activity] GO:0019827[stem cell population maintenance] GO:0019899[enzyme binding] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0033169[histone H3-K9 demethylation] GO:0043229[intracellular organelle] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0051213[dioxygenase activity] GO:0051864[histone H3-methyl-lysine-36 demethylase activity] GO:0060765[regulation of androgen receptor signaling pathway] GO:0070076[histone lysine demethylation] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity] GO:2000736[regulation of stem cell differentiation]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785[chromatin] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0019899[enzyme binding] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0033169[histone H3-K9 demethylation] GO:0043229[intracellular organelle] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0051213[dioxygenase activity] GO:0051864[histone H3-methyl-lysine-36 demethylase activity] GO:0060765[regulation of androgen receptor signaling pathway] GO:0070076[histone lysine demethylation] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0016491[oxidoreductase activity] GO:0019899[enzyme binding] GO:0032452[histone demethylase activity] GO:0032454[histone H3K9 demethylase activity] GO:0033169[histone H3-K9 demethylation] GO:0043229[intracellular organelle] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0051213[dioxygenase activity] GO:0051864[histone H3-methyl-lysine-36 demethylase activity] GO:0060765[regulation of androgen receptor signaling pathway] GO:0070076[histone lysine demethylation] GO:0140684[histone H3-tri/dimethyl-lysine-9 demethylase activity]
The Human Protein Atlas project is funded
