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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
p24.2
Chromosome location (bp)
3824127 - 4348392
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts both as a repressor and an activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q1PHJ2 [Direct mapping] GLIS family zinc finger 3 transcript variant TS10; GLIS family zinc finger 3 transcript variant TS11; GLIS family zinc finger 3 transcript variant TS7; GLIS family zinc finger 3 transcript variant TS8; GLIS family zinc finger 3 transcript variant TS9; Zinc finger protein GLIS3
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q1PHJ8 [Direct mapping] GLIS family zinc finger 3 transcript variant TS2; GLIS family zinc finger 3 transcript variant TS3; GLIS family zinc finger 3 transcript variant TS4; GLIS family zinc finger 3 transcript variant TS5; Zinc finger protein GLIS3
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q1PHJ2 [Direct mapping] GLIS family zinc finger 3 transcript variant TS10; GLIS family zinc finger 3 transcript variant TS11; GLIS family zinc finger 3 transcript variant TS7; GLIS family zinc finger 3 transcript variant TS8; GLIS family zinc finger 3 transcript variant TS9; Zinc finger protein GLIS3
Show all
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q1PHJ2 [Direct mapping] GLIS family zinc finger 3 transcript variant TS10; GLIS family zinc finger 3 transcript variant TS11; GLIS family zinc finger 3 transcript variant TS7; GLIS family zinc finger 3 transcript variant TS8; GLIS family zinc finger 3 transcript variant TS9; Zinc finger protein GLIS3
Show all
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Q1PHJ8 [Direct mapping] GLIS family zinc finger 3 transcript variant TS2; GLIS family zinc finger 3 transcript variant TS3; GLIS family zinc finger 3 transcript variant TS4; GLIS family zinc finger 3 transcript variant TS5; Zinc finger protein GLIS3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
A0A2R8YEK9 [Direct mapping] Zinc finger protein GLIS3
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Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
Phobius predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
A0A2R8YEK9 [Direct mapping] Zinc finger protein GLIS3
Show all
Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes
Show all
GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0003677[DNA binding] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
